草酸艾司西酞普兰联合针灸治疗抑郁症的疗效及安全性观察

Efficacy and Safety Observation on Escitalopram Oxalate Combined with Acupuncture Treating Depression

目的：探讨草酸艾司西酞普兰联合针灸治疗抑郁症的疗效及安全性。方法：90例抑郁症患者随机分为A、B、C组，分别用来士普、来士普联合针灸、针灸治疗，治疗前后比较三组HAMD评分、不良反应症状量表（TESS）及实验室检查。结果：治疗后三组患者HAMD评分均显著低于治疗前（P＜0.05），治疗后第1周A、B组HAMD评分显著低于C组（P＜0.05），治疗后第2、4、6周B组HAMD评分显著低于A、C组（P＜0.05）；B组总有效率显著高于A、C组（P＜0.05）；B组显著不良反应显著优于A组（P＜0.05）。结论：草酸艾司西酞普兰联合针灸治疗抑郁症疗效显著，安全性较高。

Objective：To evaluate the efficacy and safety of escitalopram oxalate combined with acupuncture treating depression. Methods：90 pa-tients with depression were randomly divided into group A, B and C, which was treated with escitalopram, escitalopram combined with acupuncture, acupuncture respectively, HAMD score, Treatment Emergent Symptom Scale （TESS） and laboratory examination of the three groups before and after treatment were compared. Results： HAMD scores of the three groups after treatment were all significantly lower than those before treatment （P〈0.05）, the first week after treatment HAMD scores of group A and B were significantly lower than that of group C （P〈0.05）, the second, fourth and sixth week after treatment HAMD scores of B group was significantly lower than that of group A and C （P〈0.05）;the total effective rate of group B was significantly higher than that of group A and C （P〈0.05）;obvious adverse reaction of group B was significantly better than that of group A （P〈0.05）. Conclusions：Escitalopram oxalate combined with acupuncture is significantly effective in depression, with higher security.