江苏省某县两岁幼儿双酚A暴露水平评估及影响因素分析

Assessment of bisphenol A exposure and influencing factors among two-year-old children living in a county of Jiangsu province

目的评估2岁幼儿尿中双酚A（bisphenol A，BPA）水平和每日摄入量及其影响因素，为进一步研究BPA对幼儿健康影响提供基础数据。方法选取某县365名幼儿，由其父母完成问卷调查并协助幼儿采集尿样，测定尿中BPA含量，估算每日摄人量及分析影响因素。结果BPA检出率为72．05％，可检出浓度范围为0．20～106．38μg／L，肌酐未校正和校正后中位值分别为0．95／μg／L和2．96μg／g。每日摄人量按肌酐估算最大值为4．596Mg／kgbw／24h，低于欧盟食品安全机构（European Food Safety Authority，EFSA）提出的BPA每日允许摄入量（tolerable daily intake，TDI）。统计分析结果显示不同性别幼儿BPA水平相似，而不同居住地间BPA水平差异有统计学意义（P〈0．05）。结论该地区2岁幼儿普遍暴露于BPA，暴露水平低于EFSA提出的TDI。

Objective To evaluate levels of urinary bisphenol A, daily intake and its influencing factors among two- year-old children. Methods Questionnaires and spot urine samples were collected from 365 children living in a county of Jiangsu province. Urinary BPA concentration was determined,daily intake was calculated and the influencing factors were i- dentified. Results The detection rate of urinary BPA was 72.05%. The detectable range was 0. 20--106.38 μg/L. The median value and the median value of BPA concentration with creatinine correction were 0.95 μg/L and 2.96 μg/g,respec- tively. The calculated maximum value of BPA daily intake was 4. 596 μg/kg bw/24 h and was lower than the tolerable daily intake（TDl）in Europe. Statistical analysis indicated that the BPA concentrations were similar between female and male chil- dren. The locations of residence had statistically significant effects on concentrations （P〈0. 05）. Conclusion The findings suggests that the two-year-old children are widely exposed to BPA in the studied county and the calculated daily intakes are lower than TDI in Europe.