5-羟色胺2A受体基因多态性与精神分裂症遗传关联性的Meta分析

Meta-analysis on inherited association between 5-hydroxytryptamine 2A receptor gene polymorphism and schizophrenia

目的：探讨5-羟色胺2A受体（HTR2A）基因T102C位点多态性与精神分裂症的关联性，为精神分裂症的遗传背景提供循证医学证据。方法：计算机检索 Pubmed、EMbase、CNKI、万方医学网和维普数据库，收集2003-2012年有关 HTR2A基因T102C多态性与精神分裂症关联性研究的文献，在全文回顾的基础上对文献进行筛选、评价和数据提取。应用 RevMan 5.1和 Stata 12.0软件对纳入的文献进行 Meta分析，依据不同种族将研究对象分为欧洲人群和亚洲人群2个亚组进行分别统计，对等位基因 C/T和不同遗传规律基因型 CC/TT、CC/CT＋TT、CC＋CT/TT及CC＋TT/CT共5种模型进行统计，包括异质性检验、合并效应量及评估发表偏倚。结果：共纳入11个研究，包括2443例精神分裂症患者和2469名健康对照者。Meta分析，等位基因总人群合并 OR＝1.12，95％CI＝0.96～1.31，P＞0.05；CC/TT遗传模型总人群合并 OR＝1.11，95％CI＝0.80～1.53，P＞0.05；CC/CT＋TT遗传模型总人群合并 OR＝1.13，95％CI＝0.99～1.30，P＞0.05；CC＋CT/TT遗传模型总人群合并 OR＝1.18，95％CI＝0.93～1.50，P＞0.05；CC＋TT/CT 遗传模型总人群合并 OR＝0.95，95％CI＝0.84～1.06，P＞0.05。结论：目前的证据不足以表明 HTR2A基因T102C多态性与精神分裂症存在关联性，提示该基因多态性与精神分裂症的遗传无显著关联性。

Objective To investigate the association between 5-hydroxytryptamine 2A receptor （HTR2A）gene T102C locus polymorphism and schizophrenia,and to provide basis for evidence-based medicine for the genetic background of schizophrenia.Methods PubMed,EMbase,CNKI,WanFang and Vip information databases were used to search full text of all the relevant studies about the association between HTR2A gene T102C locus polymorphism and schizophrenia,which were published during 2003 to 2012.Based on reviewing full text,the data were selected, evaluated and accessed. RevMan 5.1 and Stata 1 2.0 were used to perform the statistical analysis of those studies that were in accordance with the inclusive criteria. According to the different ethnicities, the obj ects were divided into two subgroups as European and Asian to analyze respectively. Also, depending on different inheritances, the obj ects were divided into five patterns including C/T allele, CC/TT, CC/CT＋TT, CC＋CT/TT and CC＋ TT/CT genotypes to analyze respectively, including heterogeneity inspection, effect consoliating and publication bias assessment. Results A total of 11 studies were available for this analysis, including 2 443 schizophrenia patients and 2 469 controls.The Meta-analysis results showed that the allele of all people were OR=1.12,95%CI=0.96-1.31,P〉0.05;CC/TT of all people were OR=1.11,95%CI=0.80-1.53,P〉0.05;CC/CT＋TT of all people were OR=1.13,95%CI=0.99-1.30,P〉0.05;CC＋CT/TT of all people were OR=1.18, 95%CI=0.93-1.50,P〉0.05;CC＋TT/CT of all people were OR=0.95, 95%CI=0.84-1.06,P〉0.05.Conclusion Current evidence is insufficient to show that HTR2A gene T102C locus polymorphism may be associated with schizophrenia, suggesting that the gene polymorphism has no significantly genetic association with schizophrenia.