摘要
目的:优选七归滴丸的成型工艺。方法:以滴丸的溶散时限、丸重变异系数、外观评分(圆整度、硬度、色泽)的综合评分为指标,在单因素试验基础上,通过正交试验考察药物-基质、滴距、料温、滴速对七归滴丸成型工艺的影响。结果:最佳成型工艺为以聚乙二醇4000为基质,药物-基质(1∶2),料温85℃,滴速45滴/min,滴距9 cm,冷却柱长110 cm,冷凝剂为液状石蜡,冷凝剂温度12℃;丸重差异<10%,溶散时限5.02 min。结论:优选的成型工艺稳定可行,制备的七归滴丸成型率高,符合滴丸制剂的质量要求。
Objective:To optimize molding technology of Qigui dropping pills.Method:Taking dissolution time of dropping pills,pill weight coefficient of variation,appearance score (roundness,hardness,color) as a comprehensive assessment index,based on single factor tests,orthogonal test was adopted to optimize molding technology by taking proportion of drug extract-matrix,dropping distance,material temperature and dropping speed as factors.Result:The best molding technology of Qigui dropping pills was as following:with polyethylene glycol 4000 as matrix,proportion of drug extract-matrix 1 ∶ 2,material temperature 85 ℃,dropping speed of 45 d ·min-1 dropping distance of 9 cm,with atolin as coolant,cooling column length of 110 cm coolant temperature at 12 ℃; dissolution time was 5.02 min,pill weight difference was less than 10%.Conclusion:This optimized molding technology is stable and feasible.These prepared Qigui dropping pills have high molding rate to meet quality requirements of dropping pills.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第20期39-42,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
山东省教育厅课题(J07YD10)
关键词
七归滴丸
成型工艺
液状石蜡
聚乙二醇
丸重差异
Qigui dropping pills
molding technology
liquid paraffin
polyethylene glycol
pill weight difference