摘要
目的:测定楤木总皂苷在水,0.1 mol·L^-1盐酸和不同pH磷酸盐缓冲液中的平衡溶解度,为楤木总皂苷提取物的剂型设计提供实验依据.方法:以楤木皂苷A为指标,采用HPLC测定楤木皂苷A在不同介质中平衡溶解度,流动相乙腈(A)-0.1%磷酸溶液(B)梯度洗脱(0 ~ 18 min,35% ~ 43% A; 18 ~ 19 min,43% A; 19~25 min,43% ~ 35% A),检测波长205 nm.结果:37℃时,楤木皂苷A在水,0.1 mol·L^-1盐酸和pH 2,4,6,7,8,10的磷酸盐缓冲液中平衡溶解度分别为1.780,0.241,0.420,0.472,1.196,1.746,0.180,0.242 g·L^-1.结论:楤木总皂苷提取物微溶于水,但受介质的pH影响大.
Objective:To establish a method for determination equilibrium solubilities of total saponins extract from Aralia chinensis in different mediums.Method:Taking araloside A as index,an HPLC method was performed and adopted to detect the concentration of araloside A in water,0.1 mol · L^-1 HC1 and different phosphate buffer with pH of 2,4,6,7,8,10 at 37 ℃,mobile phase of acetonitrile (A)-0.1% phosphoric acid solution (B) for gradient elution (0-18 min,35%-43%A; 18-19 min,43%A; 19-25 min,43%-35% A),detection wavelength was set at 205 nm.Result:Equilibrium solubilities of araloside A in different mediums were 1.780,0.241,0.420,0.472,1.196,1.746,0.180,0.242 g · L^-1.Conclusion:Total saponins extract from A.chinensis dissolves in water,its equilibrium solubility is influenced greatly by pH values.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第20期51-53,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
泸州市科技局项目(泸市科[2011]108号)
泸州医学院2013年青年基金项目(2013ZRQN084)
关键词
楤木总皂苷
楤木皂苷A
平衡溶解度
磷酸盐缓冲液
total saponins from Aralia chinensis
araloside A
equilibrium solubility
phosphate buffer