金丝草化学成分

Chemical Constituents of Pogonatherum crinitum

目的:研究禾本科金发草属植物金丝草的抗乙型肝炎病毒(HBV)活性物质基础。方法:采用硅胶柱色谱、聚酰胺柱色谱、Sephadex LH-20柱色谱并结合重结晶等方法进行分离纯化,根据理化性质和波谱数据鉴定单体化合物的结构。结果:从金丝草干燥全草的60%乙醇提取物中分离得到6个单体化合物,分别鉴定为木犀草素-6-C-β-D-鸡纳糖苷(1)、牡荆素鼠李糖苷(2)、异牡荆素-4'-O-α-L-鼠李糖苷(3)、金丝桃苷(4)、槲皮素-3-甲醚(5)、D-甘露醇(6)。结论:所有化合物均为首次从金发草属植物中分离得到。

Objective：To study the anti-hepatitis B virus （HBV） constituents of Pogonatherum crinitum.Method：The compounds were isolated and purified by recrystallization and column chromatography over silica gel,polyamide and Sephadex LH-20.Their structures were elucidated on the basis of physicochemical properties andspectral analysis.Result：Six compounds were identified as luteolin-6-C-β-D-chinovoside （1）,vitexin rhamnoside （2）,apigenin-6-C-β-D-glucopyrano-4＇-O-α-L-rhamnoside （3）,hyperin （4）,quercetin-3-O-methyl ether （5）,D-mannitol （6）.Conclusion：All compounds were isolated from the genus of Pogonatherum for the first time.