复方罗布麻片结合胺碘酮治疗冠心病室性心律失常

Fufang Luobuma Pills Combined with Amiodarone in Treatment of Coronary Heart Disease Ventricular Arrhythmia

目的:观察中药复方罗布麻片结合胺碘酮治疗冠心病室性心律失常的临床疗效。方法:选取冠心病室性心律失常患者125例,随机分为3组,联合治疗组45例采用中药复方罗布麻片结合胺碘酮治疗,胺碘酮组45例采用胺碘酮治疗,对照组35例采用普罗帕酮治疗。比较3组治疗疗效及不良反应。结果:经过治疗,联合治疗组的总有效率为95.6%,胺碘酮组的总有效率为86.7%,对照组总有效率为74.3%,两两相互比较,差异均有统计学意义(P<0.05);3组治疗后的室早数、短阵室速数均有明显改善,联合治疗组、胺碘酮组的室早数、短阵室速数均低于对照组(P<0.05),联合治疗组的室早数、短阵室速数低于胺碘酮组,差异具有统计学意义(P<0.05)。结论:采用中药复方罗布麻片结合胺碘酮和单独应用胺碘酮的治疗冠心病室性心律失常疗效均比对照组疗效明显,尤其是采用中药复方罗布麻片结合胺碘酮治疗,联合用药更加安全,是治疗冠心病室性心律失常的首选,价格低廉,用药途径方便,取得了满意的疗效,值得推广。

Objective：To observe the clinical curative effect of traditional Chinese medicine Fufang Luobuma pills combined with amiodarone in the treatment of ventricular arrhythmias coronary heart disease （VACHD）.Method：One hundred and twenty-five patients with VACHD were randomly divided into three groups.Forty-five patients in the treatment group received treatment of Fufang Luobuma pills combined with amiodarone,forty-five patients in amiodarone group received treatment of amiodarone alone,and thirty-five patients in the control group received treatment of propafenone alone.The efficacy and adverse reaction of treatment were compared among the three groups.Result：After treatment,the total effective rate in the treatment group,the amiodarone group and the control group were 95.6％,86.7％ and 74.3％,respectively,with statistically significant differences between each other groups （P ＜ 0.05）.The premature ventricular number,nonsustained ventricular tachycardia were obviously improved in the three groups after treatment,and the ventricular premature number,nonsustained ventricular tachycardia in the treatment and amiodarone groups were lower than those in the control group with statistically significant difference （P ＜ 0.05）.The premature ventricular number,nonsustained ventricular tachycardia number in the treatmentgroup were lower than that in amiodarone group with statistically significant difference （P ＜ 0.05）.Conclusion：Using Fufang Luobuma pills combined with amiodarone and amiodarone alone have efficacy in treating patients with VACHD,and the combination therapy is better and safer than amiodarone alone.It can be the preferred choice in the treatment of VACHD because of low price,convenient administration route and satisfactory curative effect,which is worthy to be applied widely in clinic.