53味清热类中药对绿脓杆菌抑菌作用的聚类分析

Cluster Analysis of 53 Chinese Antipyretic Herbs on Bacteriostatic Effects Against Pseudomonas Aeruginosa

目的:通过对53味清热类中药对绿脓杆菌的抑菌作用的聚类分析,了解它们抑菌效果的差异,指导临床用药。方法:通过药敏纸片法测定抑菌环直径和液体培养测定吸光度(A)确定中药的抑菌效果。结果:聚类分析表明清热中药抑制绿脓杆菌效果的类群与传统分类存在不一致现象。结论:临床上对于防治绿脓杆菌的感染,可选用赤芍、胡黄连、黄连、蒲公英、丝瓜络、黄芩、密蒙花等清热类中药。

Objective：The bacteriostatic effects of 53 Chinese antipyretic herbs against pseudomonas aeruginosa and their antibacterial difference were classified and confirmed by cluster analysis in order to instruct clinical administration.Method：Antibacterial effect of traditional Chinese medicine was ascertained by determination of diameter of inhibition zone K-band in liquid culture.Result：The cluster analysis showed that the classification of bacteriostatic Pseudomonas aeruginosa effects were not consistent with traditional classification of Chinese antipyretic herbs group.Conclusion：For the clinical prevention of P.aeruginosa infection,the optional Chinese antipyretic herbs were suggested as paeoniae radix rubra,picrorhizae rhizoma,coptidis rhizoma,taraxaci herba,luffae fructus retinervus,scutellariae radix,buddlejae flos,etc.