C反应蛋白对新生儿败血症早期诊断的临床意义

Clinical significance of c-reactive protein in the early diagnosis of neonatal septicemia

目的:观察C反应蛋白(CRP)在新生儿败血症的早期变化,探讨CRP在新生儿败血症早期诊断的价值。方法:回顾性分析26例新生儿败血症(败血症组)患儿以及19例同期住院非感染患儿(对照组),应用免疫比浊法测定CRP水平,并同时测定白细胞计数并观察其诊断新生儿败血症阳性率。结果:败血症组CRP≥8 mg/L阳性率为88.46%,高于对照组的5.26%(P<0.01),且CRP水平高于对照组(P<0.01)。败血症CRP检测阳性率88.46%高于白细胞的42.31%(P<0.01)。结论:CRP可为败血症的早期诊断提供参考依据。

Objective： To observe the early changes of C-reactive protein（ CRP） in neonatal septicemia and its value in the early diagnosis of neonatal septicemia. Methods： Twenty-six cases of neonatal septicemia and 19 non-infected cases were divided into the septicemia group and control group,respectively. The level of CRP detected by immunoturbidimetry and white blood cell counts between two groups were analyzed,the sensitivity,specificity and Youden index of CRP in the early diagnosis of neonatal septicemia were observed. Results： The positive rate of CRP in septicemia group（ 88. 46%） was significantly higher than that in control group（ 5. 26%）（ P〈0.01）,and the CRP level of the septicemia group was also high（ P〈0.01）. The positive rate of CRP was significantly higher than that of white blood cell in septicemia group（ P〈0.01）. Conclusions： CRP can provide the basis in the early diagnosis of neonatal septicemia.