摘要
目的探讨感染性疾病患者性别、年龄、地域、季节的基本特征及对免疫毒理学指标的影响。方法采用前瞻性、多中心、大样本、注册登记式研究方法,收集使用喜炎平注射液、痰热清注射液、热毒宁注射液3种清热解毒类中药注射剂的2445例患者,制定《喜炎平/热毒宁/痰热清注射液基本信息表》,包括患者性别、年龄、地域、季节情况,并采集患者血液样本,检测血清环磷酸腺苷(cAMP)、白细胞介素1β(IL-1β)、白细胞介素4(IL-4)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、巨噬细胞炎性蛋白1β(MIPL-1β)、前列腺素E2(PGE2)、肿瘤坏死因子-α(TNF-α)水平。结果 2445例患者中,男性占63.1%,以18岁以下儿童居多,北方地区人数略多,春季患者居多。女性患者IL-1β、cAMP、MIPL-1β、PGE2、TNF-α高于男性(P<0.05或P<0.01),儿童患者各项指标均高于其他年龄患者,北方患者IL-1β、IL-4、IL-6、IL-8、cAMP、TNF-α高于南方患者,夏季患者IL-1β、IL-8、cAMP、PGE2和TNF-α高于其他季节(P<0.01)。结论不同年龄、性别、地域与发病季节感染性疾病患者免疫毒理学指标有所不同,其可能成为影响临床诊疗决策的混杂因素。
Objective To study the basic features of gender,age,region and season in patients with infectious diseases and the effects on immune toxicology. Methods A prospective,multi-center,large sample and registered study was conducted. A total of 2 445 patients injected with Xiyanping Injection,Tanreqing Injection and Reduning Injection were collected. A basic information table of Xiyanping Injection,Tanreqing Injection and Reduning Injection was formulated. The patient information such as gender,age,geographic region and onset season was included in the table. The blood samples from patients were collected to detect the levels of cyclic adenosine monophosphate( CAMP),interleukin-1β( IL-1β),interleukin-4( IL-4),interleukin-6( IL-6),interleukin-8( IL-8),macrophage inflammatory protein-1β( MIP-1β),prostaglandin E2( PGE2) and tumor necrosis factor-α( TNF-α). Results In2 445 patients,males accounted for 63. 1%. Most patients are children under 18 years old and from the northern region. The diseases commonly appeared in the spring. The levels of IL-1β,CAMP,MIP-1β,PGE2 and TNF-α in female patients were higher than those in male patients( P〈0. 05 or P〈0. 01). The levels of the indicators in pediatric patients were higher than those in other age( P〈0. 01). The levels of IL-1β,IL-4,IL-6,IL-8,CAMP and TNF-α in patients from the northern region were higher than those in patients from the southern region( P〈0. 01). The levels of IL-1β,IL-8,CAMP,PGE2 and TNF-α in patients who caught the diseases in summer were higher than those in patients who suffered the diseases in other seasons( P〈0. 01). Conclusion The indicators of immune toxicology in patients with infectious diseases vary in age,gender,geographic region and onset season. It may become the confounding factors influencing the clinical diagnosis and treatment decisions.
出处
《中医杂志》
CSCD
北大核心
2014年第20期1781-1785,共5页
Journal of Traditional Chinese Medicine
基金
国家中医药管理局中医药行业科研专项资助项目(200907001-5-6)
关键词
感染性疾病
生物样本
炎症因子
免疫因子
infectious diseases
biological samples
inflammatory cytokines
immune factors