胞磷胆碱注射液致不良反应58例文献分析

Literature Analysis of 58 ADR Cases Induced by Citicoline Injection

目的：探讨胞磷胆碱注射液致不良反应（ADR）的一般规律和特点，为临床合理用药提供参考。方法：检索1994-2013年相关中文医药学期刊报道的胞磷胆碱注射液致ADR病例，并就收集到的58例ADR相关信息采用统计学的方法进行分类、统计和分析。结果：58例ADR患者均为静脉给药，老年患者占比较高；ADR主要发生在用药后30min内，以速发型为主；O．50～1．00g剂量范围内发生ADR的比例较高；以中枢神经系统损害较为多见；发生ADR强度以Ⅱ级为主，经停药和对症治疗后均可恢复正常。结论：胞磷胆碱注射液致ADR预后较好，但临床仍应加强用药监测，过敏体质须慎用，以确保用药安全。

OBJECTIVE： To investigate the general regularity and characteristics of adverse drug reaction （ADR） induced by Citicoline injection, and to provide reference for rational drug use in the clinic. METHODS： By retrieving ADR cases induced by Citicoline injection published by Chinese pharmaceutical journals during 1994-2013, 58 ADR cases were collected and analyzed statistically by statistics method. RESULTS： 58 cases of ADR were induced by intravenous administration, and elderly patients oc- cupied the high proportion. Most of ADR cases occurred within 30 min after medication and belonged anaphylactic type ADR, In the range of 0.50-1.00 g, ADR took up the high proportion. Main manifestation was central nervous system damage. The type of ADR mainly belonged to grade II, and all cases could recover after drug withdrawal or symptomatic therapy. CONCLUSIONS： ADR induced by Citicoline injection has good prognosis. Medication monitoring should also be strengthened in the clinic, and drugs should be used carefully for allergic anstitution to ensure medication safety.