妊娠期尖锐湿疣患者外周血Thl/Th2型细胞因子的表达及相关机制研究

Related mechanisms and expression of Thl /Th2 type cytokines in peripheral blood of patients with pregnancy genital warts(CA)

目的:针对妊娠期尖锐湿疣(CA)患者外周血Thl/Th2型细胞因子的表达及相关机制展开研究,为临床治疗提供一定的依据。方法:选取我院2011年12月至2012年12月间收治的30例处于妊娠期的尖锐湿疣患者作为本次的研究对象,即妊娠期尖锐湿疣组,并将其与另外30例非妊娠的尖锐湿疣患者进行比较,即非妊娠尖锐湿疣组。采用双抗体夹心ELLSA法检测妊娠期尖锐湿疣患者的血清白细胞介素-2(IL-2)与白细胞介素-10(IL-10)的表达,并将其与正常妊娠患者进行对比。结果:经过研究发现,妊娠期尖锐湿疣组血清IL-2的浓度明显低于与非妊娠尖锐湿疣组相比,两组对比有明显差异(P<0.05)。结论:妊娠可能会通过削弱患者的Th1型反应导加重患者的病情,而尖锐湿疣可能不会影响正常妊娠的母体免疫。

Objectives：To study the related mechanisms and expression of Thl/Th2 type cytokines in pe-ripheral blood of patients with Pregnancy genital warts （CA）to provide a basis for clinical treatment.Methods：30 patients with genital warts during pregnancy treated in our hospital from December 201 1 to December 201 2 were se-lected as study objects,namely pregnancy CA group.Another 30 non-pregnant of patients with genital warts were selected,namely non-pregnant CA group.ELLSA double antibody sandwich assay was used to test the expression of serum interleukin-2 （IL-2）and interleukin-1 0 （IL-1 0）in patients with genital warts during pregnancy.The re-sults were compared with normal pregnancy patients.Results：The serum concentration of IL-2 of pregnancy CA group was significantly lower than that of non-pregnant CA group.The difference between the two groups was statis-tically significant （P〈0.05）.Conclusion：Pregnancy may exacerbate the patient’s condition by weakening the Th1-type response in patients,and genital warts may not affect the maternal immunity of normal pregnant patients.