血糖波动对2型DM周围神经病变患者血浆同型半胱氨酸水平的影响

Blood Glucose Fluctuantion of Type 2 Diabetes Mellitus Patients with Peripheral Neuropathy Plasma Homocysteine Levels

目的：观察2型糖尿病患者在血糖波动状态下血浆同型半胱氨酸水平的变化，探讨血糖波动对糖尿病周围神经病变患者同型半胱氨酸水平的影响。方法：选取DPN患者75名分为血糖稳定组（ DPN＋1组）及血糖波动组（ DPN＋2组），30名无DPN患者（ DPN-组），以及健康对照组（ NC组），空腹检测血浆同型半胱氨酸（Hcy）、血糖（FPG）、餐后2小时血糖（2hPG）、糖化血红蛋白（HbA1c）等。结果：Hcy水平DPN＋组及DPN-组明显高于NC组（P＜0．01），DPN＋2组较DPN＋1组升高（P＜0．05）。结论：提示Hcy水平与血糖相关，且与血糖波动密切相关，Hcy水平升高是DPN的危险因素。

Objective：To observe the level of homocysteinemia in type 2 diabetes mellitus patients with peripheral neuropathy under blood glucose fluctuantion, and investigate the effect of blood glucose fluctuantion to the level of homocysteinemia in patients with pe-ripheral neuropathy. Methods：Selected seventy-five type 2 diabetes mellitus patients with peripheral neuropathy to divide into steady-blood glucose-group （ DPN＋1 group） and fluctuant-blood glucose-group（ DPN＋2 group）, thirty type 2 diabetes mellitus pa-tients without peripheral neuropathy, and control group. The level of homocysteinemia, fasting plasma glucose, 2h plasma glucose, Hb A1c in plasma was measured.Results：The levels of homocysteinemia was more higher in DPN＋1 group and DPN＋2 group than in con-trol（P〈0.01）, and was higher in DPN＋2 group than in DPN＋1 group（P〈0.05）.Conclusions： The level of homocysteinemia is closely related to plasma glucose, especially to blood glucose fluctuantion. High level of homocysteinemia is a risk factor for diabetic neuropathy in humans.