乳腺癌患者化疗中托烷司琼与格拉司琼止吐作用的疗效观察与护理

A Efficacy of Breast Cancer Patients with Chemotherapy Antiemetic Effect of Tropisetron and Granisetron

目的：观察乳腺癌患者化疗中托烷司琼与格拉司琼止吐作用的疗效及有效护理措施。方法：将96名乳腺癌病人随机的分成2组，即格拉司琼组与托烷司琼组，每组包括48名病人，2组病人皆为首次接受化学药物治疗，比较2组病人的恶心、呕吐的程度，治疗效果及相关护理。结果：对于预防乳腺癌的化疗所引起的恶心、呕吐来说，托烷司琼组的有效率为75．0％，格拉司琼组的有效率为70．8％，2组药物的疗效基本相似，P＞0．05。结论：在乳腺癌化学药物治疗中，托烷司琼与格拉司琼所起的止吐作用的疗效无统计学差异，对于临床用药来说，托烷司琼每天1次用药，与格拉司琼相比，其更为方便。在化疗过程中严密观察药物副反应，做好患者心理护理，饮食护理，可使患者顺利完成化疗周期，提高生存质量。

Objective：To observe the efficacy of tropisetron and granisetron for treating vomiting in breast cancer chemotherapy and ef-fective care measures.Methods：96 patients with breast cancer were randomly divided into tropisetron group and granisetron group,48 ca-ses in each group.The patients in two groups received the first chemotherapy.The degree of nausea and vomiting and related care as well as the effects were observed and compared.Result：The curative effective rate was 75.5%in the tropisetron group and 71.1%in the gran-isetron group,which the effects in the two groups were similar（ P〉0.05） .Conclusion：The antemetic effects of tropisetron and granisetron are basically similar.Tropisetron is taken only once a day with more convenient.The closely observed adverse drug reaction during chemo-therapy, patients with good psychological care, diet care, patients can successfully complete the chemotherapy cycle, improve the quality of life.