不同亚型食管癌反流病患者胃组织白细胞介素-1β表达差异及临床意义

The expression of interleukin 1β in the patients with typical symptoms and atypical symptoms of NERD

目的对比研究典型症状与非典型症状的非糜烂反流病(NERD)患者胃组织白细胞介素-1β(IL-1β)的差异及临床意义。方法 NERD患者70例,按照有无典型反流症状,分为2个亚型:典型症状组43例、非典型症状组27例;采用化学发光法评估不同亚型NERD患者胃组织中IL-1β的表达差异。结果与非典型症状组比较,典型症状组IL-1β水平明显降低,差异有统计学意义[(75.26±7.20)pg/mLvs.(107.22±13.13)pg/mL,P=0.039]。结论典型症状和非典型症状的NERD患者胃组织IL-1β有明显差异,提示IL-1β可能参与了不同亚型的NERD发生的机制。

Objective To study the differences and its clinical significance of the expression of interleukin 1-beta （interleukin 1 beta ,IL-1 beta） between the patients with typical symptoms and atypical symptoms of non-erosive reflux diseases（NERD） in the stomach tissue .Methods 70 cases of patients with NERD were divided into two subtypes according to the presence or absence of typical reflux symptoms ,the typical group （43 cases） ,and the atypical symptoms group （27 cases）;The interleukin-1 assay kit （chemiluminescence） was applied to assess the differences of IL-1βin stomach tissue of NERD patients with different subtypes .Re-sults Compared with the atypical symptoms group ,the concentration of IL-1 beta in typical symptoms group was obviously lower and the difference was statistically significant [（75 .26 ± 7 .20） pg/mL vs .（107 .22 ± 13 .13） pg/mL ,P=0 .039] .Conclusion Significant differences of the expression of IL-1βin the stomach tissue were found between the typical symptoms group and the a-typical symptoms group ,suggesting that IL-1βmay be involved in the occurrence of different subtypes of NERD .