人乳头瘤病毒感染与宫颈上皮内瘤变疾病进展的相关性研究

Correlative research of HPV infection and the disease progression of cervical intraepithelial neoplasia

目的探讨人乳头瘤病毒(HPV)感染对宫颈上皮内瘤变(CIN)疾病演变的影响。方法选取2010年1～12月在中国人民解放军第324医院妇产科门诊经阴道镜下活检并病理诊断为CINⅠ级的120例患者为研究对象,采用杂交捕获2代(HC-Ⅱ)方法定量检测宫颈分泌物HPV DNA的含量,并根据有无感染HPV将患者分为CINⅠ+HPV(-)组及CINⅠ+HPV(+)组,随访3年对患者进行宫颈脱落细胞学检查(TCT)及HR-HPV检测,观察患者CIN疾病演变情况。结果 CINⅠ+HPV(-)组有13.33%患者疾病进展,而CINⅠ+HPV(+)组有21.67%患者疾病进展,两组间比较差异有统计学意义(P<0.05)。结论 HPV感染在CIN的疾病进展中具有重要作用,防治HPV的感染有利于减缓CIN的进展。

Objective To investigate the HPV infection influence on the disease evolution of cervical intraepithelial neoplasia （CIN） .Methods 120 CIN grade Ⅰ patients diagnosed by under colposcopic biopsy pathology in 324th Hospital of PLA obstetrics and gynecology clinic from January to December 2010 were selected as the research objects ,concentrations of cervical secretions＇HPV DNA were detected by hybrid capture two generations（HC-Ⅱ） of quantitative method .According to HPV infection ,patients were divided into CIN Ⅰ ＋ HPV（-） and CIN Ⅰ ＋ HPV（＋ ） group and followed up for 3 years to obseve the disease evolution of CIN by means of TCT test and HR-HPV test .Results 13 .33% patients appeared disease progression in the CIN Ⅰ ＋ HPV （-） group ,while 21 .67% in the CIN Ⅰ ＋ HPV（＋ ） group ,the difference between the two groups had significantly statistical difference （P〈0 .05） .Conclusion HPV infection has an important role in the disease progression of CIN ,suggesting that the prevention and treatment of the HPV infection could slow down the progression of CIN .