未触及肿块早期乳腺癌临床特征与预后分析

Clinical features and prognosis of early breast cancer with nonpalpable mass

目的探讨未触及肿块早期乳腺癌患者的临床特征、生存率和影响预后的因素。方法回顾性分析2000年1月至2012年12月收治的121例未触及肿块的早期乳腺癌患者的临床资料,观察患者长期生存率,分析其临床特征及影响预后的因素。结果 121例未触及肿块的早期乳腺癌患者发病年龄21∽69岁,平均（44.1±10.6）岁,〈50岁者占71.1%（86/121）;64.5%（78/121）患者主要因乳头溢乳、乳腺腺体增厚等临床某一细微的早期变化进行追踪检查而发现;主要病理类型为浸润性非特殊癌[64.5%（78/121）],雌、孕激素受体均阳性者占60.3%（73/121）。5年总体生存率为84.9%,年龄、家族史、雌激素受体状况及组织病理学类型是影响患者预后的独立指标。结论未触及肿块早期乳腺癌患者具有独特的临床和病理特征,影响患者生存、预后的独立因素为年龄、家族史、雌激素受体状况及组织病理学类型。

Objective To analyze the clinical features,survival rate and prognostic factors of early breast cancer with nonpalpable mass. Methods Clinical data of 121 non-palpable early breast cancer patients treated from January 2000 to De-cember 2012 were retrospectively reviewed to analyze clinical features,survival rate and prognostic factors. Results The onset age of the 121 cases were 21-69 years old,with the average age of （44.1＆#177;10.6） years,and the patients less than 50 years account-ed for 71.1%（86/121）;64.5%（78/121） patients were found by follow-up examination of nipple discharge,thickening of mammary gland and so on;the main pathological type was infiltrative non specific cancer[64.5%（78/121）],and in estrogen and progesterone receptors,the positive accounted for 60.3%（73/121）. The 5-year survival rate was 84.9%. The age,family history,estrogen recep-tor status and tumor pathohistology were the independent prognostic factors. Conclusions Non-palpable early breast cancer ex-hibits distinctive clinical and pathological features. Age,family history,estrogen receptor status and tumor pathohistrology are in-dependent prognostic factors.