参附注射液治联合西药治疗休克随机平行对照研究

The Random Parallel Control Study of Shenfu Injection Combined Conventional Treatment of 78 Cases of Shock

[目的]观察参附注射液治联合西药治疗休克疗效。[方法]使用随机平行对照方法,将78例住院患者按病志号抽签法随机分为两组。对照组39例补充血容量、纠正水电解质紊乱、抗感染、扩血管、积极治疗原发病,去甲肾上腺素或多巴胺、多巴酚丁胺等血管活性药。治疗组39例参附注射液100mL加入0.9%氯化钠500mL,静点,输液泵控制速度,1次/12h;西药治疗同对照组。两组均连续治疗24h。观测心率(HR)、平均动脉压(MAP),每小时尿量、每4h检测动脉血乳酸(Lac)、24h时输液量、不良反应。连续治疗24h判定疗效。[结果]治疗组心率下降,平均动脉压上升,血乳酸下降及尿量增加均优于对照组,24h输液量少于对照组。治疗组疗效优于对照组(P<0.01)。[结论]参附注射液治联合西药常规疗法治疗休克效果显著,值得推广。

[ Objective] To observed the effects of Shenfu injection combined conventional treatment in treating shock. [ Methods ] Using random parallel control method.The 78 patients of shock were divided into treatment group and control group with random number table, 39 patients in each group.Control group used conventional treatment, included added blood volume and correct electrolyte disturbances and anti-infection to cure the primary disease and added vasoactive drugs if nessary.Based on conventional treatment, the treatment group added with Shenfu injection. Two groups of continuous treatment for 24 h. To evaluate the clinical effective of shenfu injection by observed heart rate （ HR ）, mean arterial pressure （ MAP ）, blood lactate （ Lac ）, urine volume, transfusion volume and untoward effect. To judge the effect after 24h treatment. [ Results ] Patients in treatment group were better than control group. [ Conclusion ] There is an obvious therapeutic effect of Shenfu injection combined conventional treatment in treating shock. It＇ s worth promoting.