黄芪注射液+艾迪注射液联合益气清毒方干预中晚期恶性肿瘤随机平行对照研究

Huangqi + Aidi Injection Combined with Advanced Cancer Randomized Parallel Group Study Fang Qi Disinfection Treatment

[目的]观察黄芪注射液+艾迪注射液联合益气清毒方干预中晚期恶性肿瘤疗效。[方法]使用随机平行对照方法,将40例住院患者按抽签法简单随机分为两组。对照组20例DCF化疗,多西紫杉醇75mg/m2,第1d静滴;5-氟尿嘧啶600mg/m2,24h内持续静滴;并加5-氟尿嘧啶2.5g^3g至化疗泵内持续点滴120h(适用于第1~5d);顺铂25mg/m2,第1~3d静滴(使用多西紫杉醇前,可常规应用甲强龙、西米替丁及非那根,以防止药物过敏)。治疗组20例1黄芪注射液10~20mL+艾迪注射液50~100mL+450mL0.9%氯化钠或5%葡萄糖,1次/d,静滴;2益气清毒方(甘草6g,陈皮10g,白术、茯苓各12g,太子参15g,藤梨根、绞股蓝各20g,半枝莲、黄芪、白花蛇舌草各30g;腹胀加木香;大便糖稀加淮山、薏苡仁;胃纳呆滞可加砂仁、神曲;大便秘结加火麻仁、杏仁;呃逆可加枇杷叶、旋覆花),1剂/d,水煎200mL,早晚口服。连续治疗30d为1疗程。观测临床症状、KPS评分、BMI指数、瘤体大小、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组临床痊愈1例,显效7例,有效10例,无效2例,总有效率90.00%。对照组临床痊愈0例,显效3例,有效8例,无效9例,总有效率55.00%。治疗组疗效优于对照组(P<0.05)。KPS评分及BMI指数治疗组优于对照组(P<0.05)。瘤体大小两组间无明显差异(P>0.05)。[结论]黄芪注射液+艾迪注射液联合益气清毒方干预中晚期恶性肿瘤效果显著,值得推广。

[ Objective ] Huangqi ＋ Aidi injection combined with the Qi Fang disinfection efficacy of the treatment of advanced cancer. [ Methods ] random parallel control method, 40 cases of hospitalized patients were randomly divided into two groups. A control group of 20 patients with chemotherapy DCF, the basic plan is：docetaxel 75mg/m2, Section l d infusion; 5 - fluorouracil 600rag/m2, continuous infusion within 24h; and plus 5 - fluorouracil 2.5g ~ 3g to chemotherapy pump continuous drip 120h （applicable to section 1 ~ 5d ） ; cisplatin 25mg/m2, the first 1 ~ 3d infusion （ docetaxel prior to use, can be routinely applied methylprednisolone, cimetidine and phenergan to prevent drug allergies ） . Treated 20 cases of anti-cancer medicine consolidate （~） righting class, Huangqi 10 ~ 20mL ＋ Aidi injection 50 ~ 100mL ＋0.9% sodium chloride injection or 5% dextrose injection 450mL, 1 times / d, intravenous infusion. （~） the Qi Qingdu party （Gancao 6g, Chenpi 10g, Baizhu, Fuling each 12g, Taizishen 15g, Tengligen, Jiaogulan each 20g, Banzhilian, Huangqi, Baihuasheshecao each 30g; bloating can add Muxiang; stool syrup plus Huaishan, Yiyiren; sluggish appetite can add Sahren, Shenqu; constipation can add Huomaren, Xingren; hiccups can add Pipaye, Xuanfuhua）, a / d, decoction 200mL, Sooner or later the oral （ during chemotherapy can also take, if the patient vomiting 3d taking significant pause again ） . 30d is a continuous course of treatment. Observation of clinical symptoms, KPS score, BMI index, tumor size, adverse reactions. 2 courses of continuous treatment, to determine efficacy. [ Results ] treatment group 1 cases, 7 cases, stable in 10 cases, 2 cases, the total efficiency of 90.00%. Control group, 0 cases markedly effective in 3 cases, stable 8 cases, 9 cases, the total efficiency of 55.00%. Treatment group than the control group （ P 〈0.05 ） . KPS score and BMI index of the treatment group than in the control group （ P 〈0.05 ） . Tumor size is equivalent to the treatment group than the control group （ P〉 0.05 ） . [ Conclusion ] Huangq ＋ Aidi injection combined with the Qi Fang disinfection treatment of advanced malignant effect is remarkable, worthy of promotion.