胃癌中MCM5蛋白的表达及临床病理意义

Expressions and clinicopathological significance of MCM5 in gastric carcinoma

目的探讨胃癌中微小染色体维持蛋白5(MCM5)的表达情况及临床病理意义。方法采用免疫组化SP法检测60例胃原发癌组织及20例正常胃黏膜组织(取自癌旁正常胃黏膜)中MCM5蛋白的表达情况,并结合临床病理参数进行综合分析。结果 MCM5在60例胃癌组织中阳性率为80.6%;在20例正常胃黏膜组织中阳性率为30%。胃癌组显著高于正常组(P<0.01)。MCM5在胃癌组中的表达与病理分级和浸润深度(T分期)有关(P<0.01;P<0.05)。结论 MCM5参与了胃癌的发生发展并可能作用于胃癌的早期阶段,其表达水平可能与胃癌病理分级、分期有关,检测其表达水平对胃癌的治疗选择和评估预后可能有重要的参考意义。

Objective To evaluate the expression of minichromosome maintenance protein 5（mcm5） in gastric carcinoma and its clinicopathological significance .Methods SP immunohistochemical stain was used to detect its expression in sample of 60 gastric cancer tissues and 20 normalgastric mucosa near the tumor .And their corresponding clinical data were comprehensive analyzed .Results The positive expression rates of mcm 5 was 80.6%in 60 gastric carcinoma and was 30%in normaltissues.Mcm5had notable differences between the gastric cancer tissues and nor-malgastric mucosa（P〈0.01）.The expression of mcm5 was closely relevant to the grade and the invasive depth（P〈0.01;P〈0.05）.Conclusions The expression of mcm5 is correlated to occurrence and development of gastric carcinoma .And it may work in the early phase in carcinogenesis of gastric carcinoma . The expression of Mcm5 is may also correlated to the grade and invasive depth and the detection of mcm 5 may have important reference significance in evaluating prognosis and guiding chemotherapy in patients with gastric carcinoma.