CRRT联合HP治疗横纹肌溶解综合征伴急性肾损伤的效果及护理

CRRT COMBINED HEMOPERFUSION IN THE TREATMENT OF RHABDOMYOLYSIS WITH ACUTE KIDNEY INJURY

目的探讨连续性肾脏替代治疗（CRRT）联合血液灌流（HP）治疗横纹肌溶解综合征（RM）伴急性肾损伤的临床疗效及护理方法。方法应用CRRT联合HP治疗RM伴急性肾损伤病人12例,给予恰当的护理,观察治疗前、治疗12、24h后病人血肌红蛋白（Mb）、肌酸激酶（CK）、肌酐（Cr）水平变化。结果与治疗前比较,治疗12、24h后病人血Mb、CK、Cr显著下降,差异有显著性（F=4.75~9.68,P〈0.05）。结论应用CRRT联合HP治疗RM伴急性肾损伤,可明显改善肾功能。

Objective To investigate the effects and nursing care of continuous renal replacement therapy （CRRT） combined hemoperfusion （HP） on rhabdomyolysis with acute kidney injury （AK]）. Methods Applying combined CRRT and HP to treat 12 patients with ARI caused by rhabdomyolysis. Serum myoglobin （Mb）, creatine kinase （CK）, creatinine （Cr） were measured-before and 12 h and 24 h after treatment. Results Compared with before treatment, the levels of myoglobin, creatlne kinase, and ereatinine dramatically decreased 12 h and 24 h after treatment （F=4.75--9.68,P〈0.05）. Conclusion Application of CRRT combined HP for rhabdomyolysis with acute kidney injury can significantly improve renal function.