转移性恶性黑色素瘤分子靶向及免疫治疗进展

Progress of Molecular Targeted Therapy and Immunotherapy for Metastatic Malignant Melanoma

黑色素瘤是恶性程度最高的皮肤肿瘤,基于对黑色素瘤细胞的基因突变和免疫系统研究的深入,分子靶向和免疫治疗药物为晚期黑色素瘤带来了新的契机。全文总结近年治疗恶性黑色素瘤靶向药物及相关治疗通路的研究进展。

Melanoma is the most aggressive tumor in skin malignancies. The molecular target and immune agents have brought new therapy opportunity for advanced melanoma,which is based on intensive studies on gene mutations of melanoma cells and immune system. The research progress of targeted agents and related treatment pathway for malignant melanoma treatment was summarized in this paper.