非酒精性脂肪性肝病发病的多因素分析

Risk factors for non- alcoholic fatty liver disease: a multivariate analysis

目的探讨影响非酒精性脂肪性肝病(NAFLD)的相关高危因素,为预防提供依据。方法对苏州大学附属第一医院自2011年1月至2013年1月就诊的190例NAFLD患者进行相应调查,内容包括:性别、年龄、身高、体质量、饮食习惯、烟酒嗜好、文化程度、职业、体育锻炼强度及时间、就寝时间、既往史、家族史等。应用统计学软件SPSS18.0对其进行单因素分析和非条件Logistic回归分析。结果单因素分析显示性别、年龄、饮食习惯、职业、体质量指数、学历与NAFLD的发生有相关性(P<0.05)。Logistic回归显示性别(OR=5.692,P=0.029)、年龄(OR=0.423,P=0.041)、职业(OR=0.698,P=0.008)、体质量指数(OR=3.939,P=0.003)、学历(OR=5.463,P=0.030)、饮食习惯(OR=9.235,P=0.039)是NAFLD的高危险因素。结论 NAFLD与多种因素有关,应针对上述危险因素采用相应预防对策。

Objective To investigate the risk factors for non- alcoholic fatty liver disease（ NAFLD） and to provide a basis for the prevention of NAFLD. Methods A total of 190 patients with NAFLD who visited the First Affiliated Hospital of Soochow University from January2011 to January 2013 were included in the study. The investigated factors included sex,age,height,weight,dietary habit,smoking and alcohol consumption,educational level,occupation,intensity and duration of physical exercise,bedtime,previous history,and family history. Univariate and multivariate analyses were performed using SPSS 18. 0 to determine the risk factors for NAFLD. Results The univariate analysis showed that sex,age,dietary habit,occupation,body mass index（ BMI）,and educational level were associated with NAFLD（ P〈0. 05）. The logistic regression analysis showed that the risk factors for NAFLD were sex（ OR = 5. 692,P = 0. 029）,age（ OR = 0. 423,P =0. 041）,occupation（ OR = 0. 698,P = 0. 008）,BMI（ OR = 3. 939,P = 0. 003）,educational level（ OR = 5. 463,P = 0. 030）,and dietary habit（ OR = 9. 235,P = 0. 039）. Conclusion NAFLD may be related to many factors,and corresponding preventive measures may reduce the development of NAFLD.