蛋白质组学研究技术在肝细胞癌诊疗中的应用

Application of proteomics in study of hepatocellular carcinoma

肝细胞癌(HCC)是世界上病死率最高的恶性肿瘤之一。蛋白质组学是前沿研究领域重要组成部分,被广泛应用于有关疾病的研究中,是目前HCC研究的重要方法。显著表达的蛋白可以被筛选出来,有望成为HCC早期诊断生物标志物、药物作用靶点以及用来预测HCC复发和预后、阐明HCC致病机制。概述了国内外对于HCC蛋白质组学在临床研究中的成果,认为蛋白质组学技术基础研究成果的临床转化,将会为HCC诊疗带来极大益处。

Hepatocellular carcinoma（ HCC） is one of the most fatal malignant tumors worldwide. As an important part of cutting- edge research fields,proteomics has been widely used in the studies of related diseases and has currently become a crucial experimental approach to research on HCC. Significantly expressed proteins can be identified as potential biomarkers for early diagnosis and targets for therapeutic drugs for HCC. Moreover,they can be used for prediction of the recurrence and prognosis of HCC,as well as for investigation of pathogenesis of the disease. The proteomic results from worldwide clinical studies of HCC are summarized,and it is suggested that the clinical application of results of basic research on HCC proteomics will bring great benefit to the diagnosis and treatment of HCC.