右美托咪定和瑞芬太尼预防气管拔管期间呛咳反应的比较被引量：3

Comparison of the effects of dexmedetomidine versus remifentanil on preventing coughing response during tracheal extubation

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摘要目的比较右美托咪定和瑞芬太尼预防气管拔管期间呛咳反应的有效性和安全性。方法将ASAⅠ～Ⅱ级接受气管插管复合全凭静脉麻醉的择期手术患者60例随机分为3组：右美托咪定组、瑞芬太尼组和对照组，每组各20例。主要研究终点为呛咳反应的发生率。结果中重度呛咳的发生率右美托咪定组和瑞芬太尼均为15％（3／20），均明显低于对照组的70％（14／20）（P〈0．05）。结论右美托咪定和瑞芬太尼均能有效预防气管拔管期间的呛咳反应。 AIM To compare the efficacy and safety of dexmedetomidine and remifentanil on preventing coughing response during tracheal extubation. METHODS Sixty ASA Ⅰ～Ⅱ patients received total intravenous anesthesia were randomly assigned to receive one of three treatment regiments as follows ： dexmedetomidine group （group R） and control group （group C）（n = 20 for each group）.The primary study group （ group D）, remifentanil end-point was coughing incidence. RESULTS The prevalence of moderate or serious coughing before extubation in group D and group R were both 15 % （3/20）, which were significantly lower than that in control group （70 %, 14/20）（ P 〈 0.05 ）. CONCLUSION Dexmedetomidine and remifentanil are both effective in preventing coughing response during tracheal extubation.

作者栾海星林杨刘风

机构地区厦门大学附属第一医院麻醉科

出处《中国临床药学杂志》 CAS 2014年第5期300-303,共4页 Chinese Journal of Clinical Pharmacy

关键词右美托咪定瑞定太尼气管拔管呛咳 dexmedetomidine remifer.tanil tracheal extubation coughing

分类号 R614 [医药卫生—麻醉学]

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