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MicroRNAs在早期胚胎发育中的研究进展 被引量：4

Research advances of MicroRNAs in early embryonic development
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摘要 MicroRNAs(miRNAs)是一类长约22个左右的核苷酸组成的非编码小分子RNA,主要通过抑制靶蛋白翻译,或者降解靶基因mRNA,来负性调控基因的表达。如今miRNAs的种类发现越来越多,在很多方面发挥了作用,例如细胞的增殖、分化、凋亡、早期胚胎的发育。文中仅就miRNAs的合成机制和功能,主要检测方法及在早期胚胎发育中的研究现状作一综述。 MicroRNAs（miRNAs） is a class of small endogenous noncoding RNAs with 22 nucleotides.They can negatively regulate gene expression by inhibiting target mRNAs′translation or degrading mRNAs .Up to now, it has been proved that miRNAs play an important role in cellular proliferation , apoptosis , cell differentiation , and embryonic development .In this article , mechanism and function of miRNAs , principal methodologies in the research of miRNAs and the latest development of miRNAs in early embryonic de -velopment are discussed .
作者 江胜林 凌秀凤 张军强
机构地区 南京医科大学附属南京市妇幼保健院生殖医学中心
出处 《医学研究生学报》 CAS 北大核心 2014年第9期986-989,共4页 Journal of Medical Postgraduates
基金 国家自然科学基金(81100420 81270701)
关键词 MICRORNAS 作用机制 早期胚胎发育 MicroRNAs Mechanism Early embryonic development
分类号 Q52 [生物学—生物化学]
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共引文献45

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医学研究生学报
2014年 第9期

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