糖尿病肾病病人营养状况及其与血清胱抑素C水平的相关性分析

The nutritional status of the diabetic nephropathy patients and its relation with Cystatin C levels

目的:评估糖尿病肾病(DN)病人的营养状况,探讨其与血清胱抑素C(CysC)水平的相关性。方法:调查DN的住院病人73例,采用膳食调查、体格检查、实验室检查、主观全面性营养评估(SGA)法综合评价病人的营养状况,根据营养评价结果分为营养良好组(A组),轻-中度营养不良组(B组)和重度营养不良组(C组),所得数据经软件统计分析各组病人的CysC水平差异。结果:被调查DN病人中营养不良发生率为74.7%,血CysC水平与血红蛋白、清蛋白、肱三头肌皮皱厚度、淋巴细胞计数呈负相关。结论:DN病人的营养不良发生率较高,与DN肾功能损害程度、膳食结构不合理密切相关。其营养状况与血CysC水平存在相关性。DN病人血CysC水平升高者尽早进行营养干预,防止或减缓营养不良和其他并发症的发生。

Objective：To evaluate the nutritional status of patients with diabetic nephropathy （DN）,and to explore its relationship with serum cystatin C （cystatin C） levels.Methods：73 patientswith DN were studied using 24 h dietary survey,physical measurements,laboratory tests and subjective global assessment （SGA） method to determine the nutritional status,and the cystatin C was determined.Results：Malnutrition 74.7％ in the DN patients.Serum CysC was negatively correlated with hemoglobin,albumin,triceps skinfold thickness and lymphocyte count.Conclusion：The incidence of malnutrition is higher in patients with DN.The nutritional status and Serum CysC is correlated.