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急性肺损伤和急性呼吸窘迫综合征发病机制的研究现状与展望 被引量：11

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摘要 急性肺损伤（acute lung jnjury,ALI）和急性呼吸窘迫综合征（acute respiratory distress syndrome,ARDS）是一种急性弥漫性肺部炎症性肺损伤,伴随肺泡-毛细血管膜通透性增加所致的肺水肿,临床主要特征为低氧合、低肺顺应性、生理死腔增加及X线双肺斑片影.此定义基于近年来的研究,且认为ALI与ARDS的病因及发病机制均相同,仅仅是氧合受损程度及临床表现轻重不一,而且此二者是同一综合征的病情差别的表现,所以2011年欧洲危重症协会的柏林定义[1]去除了ALI,将ALI归入ARDS,根据ARDS病情严重程度分为轻、中、重三个亚型.
作者 徐思娟 彭再梅
机构地区 中南大学湘雅二医院急诊科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2014年第10期1179-1182,共4页 Chinese Journal of Emergency Medicine
基金 湖南省自然科学基金资助项目（14JJ7013）
关键词 急性呼吸窘迫综合征 急性肺损伤 发病机制 病情严重程度 ARDS 临床表现 急性弥漫性 ALI
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献2

二级参考文献11

  • 1He-Shui Wu, Lei Zhang, Yan Chen, Xing-Jun Guo, Lin Wang, Jian-Bo Xu, Chun-You Wang and Jing-Hui Zhang Center of Pancreatic Surgery Laboratory of General Surgery Affiliated Union Hospital of Tongji Medical College, Hua-zhong University of Science and Technology, Wuhan 430022, China,Pe-diatric Department, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China..Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis[J].Hepatobiliary & Pancreatic Diseases International,2005,4(4):609-613. 被引量：12
  • 2Bismuth C, Scherrmann JM, Garnier R,et al. Elimination of, paraquat.Hum Toxicol, 1987,6:63-67.
  • 3贺晓艳,孙琦,李忠旺.等.急性百草枯巾毒大鼠肺组织炎症因子表达的变化及意义.在华劳动卫生职业病杂忠,2009.27:149-152.
  • 4Franks ME, Macpherson GR,Figg WD. Thalidomide.hancet,2004,363:1802-1811.
  • 5Bus JS, Aust SD,Gibson JE,et al. Paraquat toxicity: proposed mecha- nism of action involving lipid peroxidation. Environ Health Per- speet, 1976,16:139-146.
  • 6Tomita M, Okuyama T, Katsuyama H, et al. Mouse model of paraquat- poisoned lungs and its gene expression profile. Toxicology, 2007,231:200-209.
  • 7Schmidt C, Peng B, Li Z, et al. Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation.Mol Ce11,2003,12: 1287-1300.
  • 8Sampaio EP, Sarno EN, Galilly R, et al. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med,1991,173:699-703.
  • 9Schmidt KN, Amstad P, Cerutti P, et al. The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. Chem Biol, 1995,2:13-22.
  • 10Moreira AL, Sampaio EP, zmuidzinas A, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med,1993,177:1675-1680.

共引文献24

同被引文献120

  • 1陈伟,宋立强.肺源性急性呼吸窘迫综合征患者预后影响因素研究[J].实用心脑肺血管病杂志,2020,0(1):43-48. 被引量：8
  • 2余剑波,姚尚龙,袁世荧,杨艳.血红素氧合酶-1对内毒素休克大鼠肺组织的保护功能[J].中华急诊医学杂志,2004,13(11):739-741. 被引量：6
  • 3陈旭岩,汪波,谭伟,熊辉,李秀清,高雨松,田亚男,刘新民.蛋白酶抑制剂对内毒素致大鼠急性肺损伤的保护作用[J].北京大学学报（医学版）,2005,37(4):398-401. 被引量：10
  • 4Schlegel N, Waschke J. cAMP with other signaling cues converges on Racl to stabilize the endothelial barrier - a signaling pathway compromised in inflammation [ J]. Cell Tissue Res, 2014, 355 (3) : 587-596.
  • 5Copsel S, Gareia C, Diez F, et al. Muhidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and eontrols human leukemia cell proliferation and differentiation [ J ]. J Biol Chem, 2011, 286 (9) : 6979-6988.
  • 6Lee WL, Slutsky AS. Sepsis and endothelial permeability [ J ]. N Engl J Med, 2010, 363 (7) : 689-691.
  • 7Curry FR, Noll T. Spotlight on microvascular permeability [ J ]. Cardiovasc Res, 2010, 87 (2): 195-197.
  • 8Kumar P, Shen Q, Piveni CD, et al. Molecular mechanisms of endothelial hyperpermeability: implications in inflammation [ J ]. Expert Rev Mol Med, 2009, 11: el9.
  • 9Schlegel N, Waschke J. Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endothelium [ J ]. Microcirculation, 2009, 16 (6) : 521-533.
  • 10Schlegel N, Baumer Y, Drenckhahn D, et al. Lipopotysaccharide- induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro [ J]. Crit Care Med, 2009, 37 (5): 1735-1743.

引证文献11

二级引证文献26

中华急诊医学杂志
2014年 第10期

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