摘要
目的探讨老年男性血清25-羟维生素D[25(OH)D]、甲状旁腺激素(PTH)水平与代谢综合征(MS)及其各组分的相互关系。方法采用横断面研究方法,收集2012年5—6月在解放军总医院行常规年度体检、年龄≥60岁老年男性1729例,平均年龄(75±10)岁。测量身高、体重、血压、血糖、血脂、碱性磷酸酶、血钙和磷、25(OH)D及PTH水平,分析25(OH)D、PTH水平与代谢综合征及其各组分的相互关系。结果本研究人群MS患病率为22.0%(380/1729)。MS组胛H水平为(42±16)ng/L,高于非MS组的(40±17)ng/L,差异有统计学意义(t=0.163,P〈0.05);高血糖组PTH水平为(42±16)ng/L,高于血糖正常组的(40±17)ng/L,差异有统计学意义(t=0.306,P〈0.05);低HDL-C组PTH水平为(47±18)ng/L,高于HDL-C正常组的(40±16)ng/L,差异有统计学意义(t=2.724,P〈0.05),而25(OH)D在各代谢异常组与正常组之间比较差异无统计学意义。随PTH五分位水平升高,MS患病率呈增加趋势;当校正25(OH)D等混杂因素后,最高值Q5组与最低值Q1组比,MS患病风险增加1.51倍(95%CI:1.03~2.23)。Logistic多元回归分析表明,PTH是影响MS的危险因素之一(OR=1.007,95%CI:1.000~1.014,P=0.047),25(OH)D与MS无关(OR=1.004,95%CI:0.992~1.016,P=0.538)。结论老年男性PTH水平升高可能增加MS的患病风险,而25(OH)D与MS未见明显相关。
Objective To explore the association of 25-hydroxyvitamin D (25 (OH)D) and parathyroid hormone (PTH) with metabolic syndrome (MS) and its components in aged males. Methods For this cross-sectional study, 1 729 aged males aged over 60 years were selected from participants in a routine annual health examination at our hospital from May to June 2012. Their mean age was 75 ± 10 years. Height, weight, blood pressure, blood glucose, blood lipids, alkaline phosphatase, calcium, phosphorus, 25(OH) D and PTH were measured. And the associations of 25 (OH)D and PTH with the presence of MS and its components were analyzed. Results The prevalence of MS was 22. 0% . The PTH levels were significantly higher in the MS and abnormal blood glucose and HDL-C group than in their control group [ (42 ±16) vs (40 ±17), (42 ± 16) vs (40 ± 17), (47 ± 18) vs (40 ± 16) ng/L respectively, P 〈 0.05 ]. However, there were no significant differences of 25 (OH) D between these groups. The prevalence of MS showed a gradual increase according to the PTH quintiles ( P 〈 0. 05 ). When comparing the subjects in the highest and lowest quintile of PTH, the former group demonstrated a 1.51-fold increase in odds ratio for MS after adjusting for 25 (OH) D levels and other confounding factors. Logistic regression analysis showed that the PTH level was an independent influeneing factor for MS in aged males ( OR = 1. 007, 95% CI: 1. 000 - 1. 014, P =0. 047). The levels of 25 (OH) D were not associated with MS in the regression model ( OR = 1. 004, 95% CI: 0. 992 - 1. 016, P =0. 538). Conclusion In aged males, the elevated level of FFH is a risk factor for the prevalence of MS. However, there was no association between 25 (OH) D and MS.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2014年第36期2828-2832,共5页
National Medical Journal of China
基金
全军保健专项科研课题(12BJZ41)
解放军总医院苗圃基金(12KMM41)
解放军总医院南楼青年创新基金(NQ201210)