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成人胰岛素样生长因子-1检测的临床价值

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摘要 胰岛素样生长因子-1（IGF-1）是反映生长激素（GH）生物功能的灵敏指标，是评估GH—IGF轴功能的重要依据。由于GH是脉冲式分泌，半衰期短，而且受饮食、运动、应激和血糖等因素的影响较大，相比之下，IGF-1为小分子多肽，与高亲和力的运载蛋白结合存在于外周血中，半衰期较长，影响GH水平的众多干扰因素对IGF-1水平影响甚微。因此，IGF-1水平相对更稳定，是评估GH—IGF轴功能的最重要介质，IGF-1检测的临床价值比GH更为重要。本文对IGF-1的检测方法以及影响因素、IGF-1和GH测定值的关系和解读方法进行综述，以期帮助指导成人肢端肥大症和成人GH缺乏症（AGHD）的临床诊治。
作者 殷琪淇 王宇 何薇 季文 李海 邓婉萍 李延兵 廖志红
机构地区 中山大学附属第一医院内分泌科
出处 《中华神经外科杂志》 CSCD 北大核心 2014年第10期1075-1078,共4页 Chinese Journal of Neurosurgery
关键词 人胰岛素样生长因子-1 临床价值 检测 IGF-1 GH缺乏症 半衰期较长 脉冲式分泌 小分子多肽
分类号 R587 [医药卫生—内分泌]
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参考文献34

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中华神经外科杂志
2014年 第10期

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