成纤维细胞生长因子19(FGF19)与脂代谢的研究进展

Research progress on the association of fibroblast growth factor 19(FGF19) with lipid metabolism

成纤维细胞生长因子19(fibroblast growth factor 19,FGF19)是在回肠末端特异性合成并分泌的细胞因子,属于FGFs的特殊成员之一。近年来自动物及细胞学的研究发现,FGF19不仅在胆汁酸代谢的调节中发挥重要作用,而且与多种心血管疾病危险因素密切相关。流行病学研究显示,2型糖尿病、代谢综合征及肥胖者FGF19水平降低。深入研究FGF19的生物学意义可能为肥胖及血脂紊乱的防治提供新的靶点。本文将介绍FGF19与脂代谢相关性的研究进展。

Fibroblast growth factor 19 （FGF19）, a special member of fibroblast growth factor family,is mainly synthesized and secreted specifically by the intestinal epithelium. Recently, results from animal and cell studies have demonstrated that FGF19 is not only function as a regulator of human bile acid metabolism, but also involved in the regulation of risk factors of cardiovascular disease. Epidemiologieal studies have also indicated that FGF19 levels decrease in subjects with type 2 diabetes, metabolic syndrome and obesity. Further studies in the pathophysiological functions of FGF19 might contribute to the treatment of obesity and dyslipidemia. The current review introduces the study progress on the association of FGF19 with lipid metabolism.