原发性高血压所致肾脏早期改变的3.0T功能磁共振研究

Early Abnormalities of Kidneys in Patients with Primary Hypertension by 3.0T Functional Magnetic Resonance Imaging

为研究3.0T肾脏功能磁共振成像(fMRI)在原发性高血压所致肾脏早期改变方面的应用,对26名原发性高血压患者(高血压组)和33名正常志愿者(对照组)进行磁共振成像(MRI)常规及功能序列扫描,包括血氧水平依赖(BOLD)成像、弥散加权成像(DWI)及弥散张量成像(DTI)。测量肾脏皮质、实质厚度,皮、髓质R2*值、表观弥散系数(ADC)以及各项异性分数(FA),计算皮质/实质厚度比。与对照组相比,高血压组皮质厚度、皮质/实质厚度比增大(P<0.01),皮、髓质R2*值增高(P<0.01),髓质FA值降低(P<0.05)。总之,3.0T肾脏功能磁共振成像有助于临床发现原发性高血压患者肾脏早期改变。

This study aims to detect early changes of kidney in patients with primary hypertension by 3.0Tfunctional magnetic resonance imaging（fMRI）.26 patients with primary hypertension（hypertension group）and 33 healthy volunteers（control group）underwent conventional and functional magnetic resonance scans,which included blood oxygen level-dependent（BOLD）MRI,diffusion weighted imaging（DWI）and diffusion tensor imaging（DTI）.We measured renal cortical thickness（CT）,parenchymal thickness（PT）,and functional values of renal cortex and medulla including R2＊value,apparent diffusion coefficient（ADC）value and fractional anisotropy（FA）value in each group,and then calculated the cortical/parenchymal thickness ratio（CPR）.Compared with those in the control group,CT and CPR in hypertension group were larger（P〈0.01）,cortical and medullar R2＊values increased（P〈0.01）whereas medullar FA values decreased（P〈0.05）.It could be well concluded that noninvasive 3.0Tfunctional MRI would have important clinical significance in identifying early abnormalities of kidney in hypertension patients.