非小细胞肺癌患者血清中胰岛素样生长因子-1水平的变化

Changes of serum insulin like growth factor-1 in patients with non-small cell lung cancer

目的 探讨非小细胞肺癌（NSCLC）患者血清中胰岛素样生长因子-1（IGF-1）的表达水平及其在NSCLC疗效评价中的临床价值.方法 采用放射免疫分析法（RIA法）检测63例NSCLC患者及32例健康体检者血清IGF-1水平,并比较44例NSCLC患者手术前后血清IGF-1水平.结果 血清IGF-1水平与NSCLC患者性别、年龄、病理类型无明显相关,与临床分期明显相关;NSCLC患者血清IGF-1水平为（258.22±52.49） μg/L明显高于健康查体者[（155.04 ±21.37） μg/L],两者差异有统计学意义（P＜0.01）;Ⅳ期NSCLC血清IGF-1水平[（322.0S ±27.46） μg/L]明显高于Ⅲ期患者[（2S0.42 ±26.12） μg/L]、Ⅲ期患者明显高于Ⅱ期[（241.59 ±22.84） μg/L]、Ⅱ期患者明显高于Ⅰ期患者[（195.20±19.27） μg/L]、Ⅰ期明显高于正常对照组,两两比较差异有统计学意义（P＜0.05）;NSCLC患者手术后血清IGF-1水平[（59.17 ±6.06） μg/L]明显低于手术前[（59.17 ±6.06） μg/L],两者差异有统计学意义（P＜0.01）.结论 血清IGF-1可作为NSCLC病情及疗效评估的参考指标.

Objective To explore the serum expression of insulin like growth factor-1 （IGF-1） in patients with non-small cell lung cancer （NSCLC） and its clinical significance in the evaluation of treatment outcome.Methods The level of serum IGF-1 was measured by radioimmunoassay （RIA） in 32 cases of normal control subjects and 63 cases of NSCLC,and compared in 44 patients with NSCLC before and after operation.Results The serum IGF-1 was correlated with clinical stage of patients with NSCLC,but not with sex,age and pathologic types.The levels of serum IGF-1 were elevated in all subgroups of patients with NSCLC [（258.22 ± 52.49） μg/L] compared to the controls [（155.04 ± 21.37） μg/L] （P 〈0.01）.The serum IGF-1 level in stage Ⅳ [（322.08 ± 27.46） μg/L] was higher than that in stage Ⅲ [（280.42 ±26.12） μg/L] （P〈0.01）,that in stage Ⅲ was higher than that in stage Ⅱ [（241.59 ± 22.84） μg/L] （P 〈 0.05）,that in stage Ⅱ was higher than in stage Ⅰ [（195.20 ± 19.27） μg/L（P 〈0.01）,and that in stage Ⅰ was higher than that in normal control subjects （P 〈0.01）.The level serum IGF-1 was obviously reduced in patients with NSCLC after operation （P 〈 0.01）.Conclusion Detection of serum IGF-1 may be a useful reference index to state the illness and evaluate the therapeutic effect of NSCLC.