过氧化物酶体增生物激活受体γ及其激动剂在眼科疾病中的作用

The role of peroxisome proliferator-activated receptors and its agonist in the ophthalmology

过氧化物酶体增生物激活受体（PPARs）是配体依赖的核激素受体超家族成员转录因子，目前已有PPARν、PPARβ／δ和PPARν3种亚型，其中PPARν与纤维化疾病的关系日益引起人们的关注。PPARν由激动剂激活后通过控制炎症反应、抑制细胞的增生、诱导细胞的凋亡和分化、抑制血管形成及抗氧化等不同机制发挥抗纤维化作用，有望成为眼部纤维化疾病治疗的一个新途径。从PPARs及其分布、PPARν的结构与功能、PPARν配体及激动剂、PPARν的活化、PPARν在眼组织的表达、PPARν与眼部疾病几个方面就PPARν及其激动剂在眼部疾病中的作用进行综述。

Peroxisome proliferator-activated receptors （PPARs） belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors. To date, three isotypes of PPARs called PPARα, PPARν/ and PPARβ/δ have been identified. The relationship between PPARν and fibrosis disease has increasingly drawn people＇s attention. PPARν is activated by its ligands or agonists plays an important role in the control of fibrosis through their effects on various cellular processes,including anti-inflammatory,inducing cellular apoptosis and differentiation, anti- angiogenesis,antioxidative and anti-proliferative effects,which is expected to be a new way to treat ocular diseases. The role of PPAR-ν and its agonist in ocular diseases,including PPARs and its distribution, the structure and function of PPAR-ν, PPAR-ν/ ligands and agonist, activation of PPAR-ν, PPAR-ν in the expression of eye tissues, and the role of PPAR-ν and its agonist in ocular diseases were reviewed.