口腔扁平苔藓患者免疫功能状况与临床特征相关性分析

The correlation analysis of immune status and clinical characters in OLP patients

目的:分析口腔扁平苔藓(OLP)患者免疫状况与临床特征的关系。方法:用流式细胞术及散射比浊法分别检测197例OLP患者(网纹型61例,充血糜烂型136例)细胞免疫(CD3+、CD4+、CD8+、CD19+、CD16++56+、CD4+/CD8+)及体液免疫(IgG、IgA、IgM、C3、CH50)状况。结果:与实验室标准正常值相比,OLP患者CD3+、CD4+降低,CD19+增高;IgG、IgM、CH50增高,IgA、C3降低。网纹型OLP患者CD16++56+、CD4+/CD8+低于正常值;充血糜烂型OLP患者CD8+低于正常值。充血糜烂型OLP患者CD3+、CD8+较网纹型降低,CD4+/CD8+较网纹型升高(P<0.05)。结论:OLP患者存在不同程度的细胞免疫功能降低,体液免疫功能紊乱,以亢进为主。不同临床类型的OLP患者免疫状况存在一定的差别。

Objective：To analyze the characteristics of immune status in patients with different types of oral lichen planus（OLP）. Methods：197 cases of OLP,61 with reticular OLP（ROLP）and 136 with hyperaemia erosion OLP（HEOLP）were included.The im-mune status of the patients were investigated by flow cytometry （FCM）for the expression of CD3 ＋,CD4 ＋,CD8 ＋,CD19 ＋,CD16 ＋＋56 ＋and CD4 ＋/CD8 ＋cells,and nephelometry for the measurements of IgG,IgA,IgM,C3 and CH50 in peripheral blood.The la-brotary norm was used as the reference and the characteristics of immune status in patients with different clinical characters of OLP were analyzed by SPSS 16.0.Results：CD3 ＋,CD4 ＋,IgA and C3 decreased,CD19 ＋cells,IgG,IgMand CH50 increased in patients with OLP.CD16 ＋＋56 ＋,CD4 ＋/CD8 ＋cells decreased in the cases with ROLP（P〈0.05）;CD8 ＋cells decreased in the cases with HE-OLP.CD3 ＋,CD8 ＋cells were fewer in HEOLP patients than that in ROLP,CD4 ＋/CD8 ＋cells were more in HEOLP than that in ROLP（P〈0.05）.Conclusion：There are defects of cellular immune function and increase of humoral immune in patients with OLP. The patients with different clinical types of OLP may have different immune fuction changes.