泛素样蛋白-蛋白酶体系统与结核分枝杆菌致病性的相关性研究进展

Research progress about the relationship between the pup-proteasome system and the pathogenicity of Mycobacterium tuberculosis

结核分枝杆菌(Mycobacterium Tuberculosis,MTB)中的泛素样蛋白-蛋白酶体系统(prokaryotic ubiquitin-like protein-proteasome system,PPS),主要介导和调控MTB体内蛋白质的降解。在特定环境下,MTB中泛素样蛋白(prokaryotic ubiquitin-like protein,Pup)选择性标记特定的蛋白质,并在辅助因子的帮助下将靶蛋白送入蛋白酶体内降解,对MTB在宿主体内的生长、繁殖及致病性发挥重要调控作用。本文首先简单介绍了MTB中Pup、蛋白酶体的结构特点、作用及PPS降解靶蛋白的主要过程,接着重点介绍了PPS对MTB致病性的调控机制,及如何通过改变PPS作用来降低MTB致病性等一些最新进展,希望能够为寻找新型抗结核药物提供方向。

The pup-proteasome system of Mycobacterium tuberculosis is the most basic and important control system which could induce changes in the external environment, and make the corresponding reaction. In a particular context, prokary- otic ubiquitin-like protein in Mycobacterium tuberculosis marks the specific proteins selectively. It sends the target protein into proteasome with the help of cofactors, and playing an important role in growth, multiplication and pathogenicity in host body. In this article, we first introduce structural characteristics and function of the prokaryotic ubiquitin-like protein and protea- some, and the main proceses of the prokaryotic ubiquitin-like protein-proteasome system target protein degradation. Then we mainly introduce some of the latest progress, such as the regulatory mechanism of PPS for MTB pathogenic, and how to reduce the MTB pathogenic role by changing the PPS, etc. , providing direction for looking for new anti-tuberculosis drugs.