弓形虫与宿主细胞相互作用研究进展

Interaction between toxoplasma gondii and host cell

刚地弓形虫(Toxoplasma gondii)在细胞内严格寄生,因此它能引起哺乳类宿主(包括人类)细胞的感染。凋亡在宿主细胞与弓形虫的相互作用中发挥着重要的作用。在未受感染的宿主细胞中,凋亡被间接机制所限制,因而宿主细胞能够对弓形虫发生炎症反应。与之相反,在被感染的宿主细胞中,由于凋亡信号级联反应直接受到了干扰,从而抑制了宿主细胞凋亡,这就有利于弓形虫在宿主细胞内的生存和发育。值得注意的是,弓形虫调节和抑制凋亡的两种能力,需要一个精密的调节系统来调控弓形虫和宿主细胞的相互作用,以维持弓形虫稳定的持续感染。重点从弓形虫有关的宿主细胞的凋亡方面进行了介绍。

Infection with the strict intracellular protozoan Toxoplasma gondii （ T.gondii） leads to lifelong persistence of the parasite in its mammalian hosts including humans .Apoptosis plays crucial roles in the interaction between the host and the parasite.After infection, apoptosis is triggered in T lymphocytes and other leukocytes , thereby leading to suppressed im-mune responses to the parasite .Apoptosis is restricted by indirect mechanisms in uninfected bystander cells , thereby modu-lating the inflammatory response to the parasite .On the contrary , inhibition of apoptosis in infected host cells by a direct interference with apoptosis-signaling cascades is thought to facilitate the intracellular development of T.gondii.The inter-esting dual activities of T.gondii to both promotion and inhibition in apoptosis require a compact regulation to promote a stable parasite host-interaction and establishment of continuous toxoplasmosis .This article focused on T gondii related host cell apoptosis .