橄榄-脑桥-小脑萎缩与“十字征”八例

Olivopontocerebellar atrophy and cross sign eight casese

目的探讨MRI脑桥十字征的橄榄-脑桥-小脑萎缩(OPCA)患者临床与影像学特点。方法总结8例经临床诊断为OPCA,分析其临床特点及影像学特征表现。结果 8例患者的临床表现均以小脑性共济失调和脑干功能受损伴有自主神经功能障碍为主,MRI在脑桥轴位T2WI上均出现典型的"十字征"。结论以小脑性共济失调和脑干功能受损为主要表现的OPCA患者,多伴有自主神经功能障碍,脑桥十字征是MRI特征性表现之一,有助于该病的诊断。

Objective To explore the clinical and M RI features of olivopontocerebellar atrophy（OPCA） patients with pontine cross sign,which was regarded as the characteristic change.Methods Clinical data and MRI features of eight OPCA patients were analyzed respectively.Results All the eight patients were manifested with cerebellar signs、brainstem signs and autonomic nerve signs,cross sign was the typical MRI feature of T2 WI in pontine axial position.Conclusion The OPCA patients featured with cerebellar sign and brainstem sign are also accompanied by autonomic nerve signs,Pontine cross sign is the most significant MRI feature,which contributed to the final diagnosis.