癫痫与海马神经再生

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摘要癫痫是常见的神经系统疾病,在世界范围约5千万人患有癫痫.癫痫患者中30％经抗癫痫药物治疗后症状无改善,癫痫的治疗急需进一步研究新的药物作用靶点[1-2].近年来发现,在癫痫动物模型和癫痫患者中,均存在新生神经元的数量改变,即神经再生的改变[3-4].本文介绍近年来关于癫痫中神经再生的进展.

作者赵冉冉徐晓臣王维平焦清海

机构地区邯郸市第一医院急诊科河北医科大学第二医院神经内科

出处《脑与神经疾病杂志》 2014年第5期386-390,共5页 Journal of Brain and Nervous Diseases

关键词神经再生抗癫痫海马神经系统疾病药物作用靶点癫痫动物模型药物治疗癫痫患者

参考文献62

1Brodie MJ,Shorvon SD,Canger R,et al.Commission on European Affairs:appropriate standards of epilepsy care across Europe.ILEA.Epilepsia,1997,38:1245-1250.
2Kwan P,Brodie MJ.Early identification of refractory epilepsy.N Engl J Med,2000,342:314-319.
3Zhu H,Dahlstrom A,Hansson HA.Characterization of cell proliferation in the adult dentate under normal conditions and after kainate induced seizures using ribonucleotide reductase and BrdU.Brain Research,2005,1036:7-17.
4Smith PD.,Mclean KJ,Murphy MA,et al.Seizures,nothippocampal neuronal death,provoke neurogenesis in a mouse rapid electrical amygdala kindling model of seizures.Neuroscience,2005,136:405-415.
5Altman J.Are new neurons formed in the brains of adult mammals Science,1962,135:1127-1128.
6Eriksson PS,Perfilieva E,Bjork-FFEriksson T,et al.Neurogenesis in the adult human hippocampus.Nat Med,1998,4:1313-1317.
7Snyder JS,Hong NS,McDonald RJ,et al.A role for adult neurogenesis in spatial long-FFterm memory.Neuroscience,1999,130:843-852.
8Song H,Stevens CF,Gage FH.Astroglia induce neurogenesis from adult neural stem cells.Nature,2002,417:39-44.
9Lie DC,Colamarino SA,Song HJ,et al.Wnt signaling regulates adult hippocampal neurogenesis.Nature,2005,437:1370-1375.
10Lim DA,Tramontin AD,Trevejo JM,et al.Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.Neuron,2000,28:713-726.

脑与神经疾病杂志

2014年第5期

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