摘要
Astrocyte elevated gene-1（AEG-1） is associated with tumor genesis and progression in a variety of human cancers.This study aimed to explore the significance of AEG-l in glioma and investigate whether it correlated with radioresistance of glioma cells.Immunohistochemical staining showed that the intensity of AEG-l,CD133 and PPP6 c protein expression in glioma tissues increased significantly,mainly in the cytoplasm.The expression rate of AEG-l,CD133 and PPP6c were 85.9%（67/78）,60.3%（47/78） and 65.8%（51/78）,respectively.AEG-l expression was correlated with age（r=0.227,P=0.045）,clinical stage（r=0.491,P〈0.001） and clinical grade（r=0.450,P〈0.001）.No correlation was found between AEG-l expression and other clinicopathologic parameters（P〉0.05）.The expression of AEG-1 was positively correlated with the expression of CD133（r=0.240,P = 0.035） and PPP6c（r= 0.250,P = 0.027）.In addition,retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-l and PPP6 c in glioblastoma.Our findings indicate that AEG-l is positively correlated with CD133 and AEG-l expression.It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
Astrocyte elevated gene-1（AEG-1） is associated with tumor genesis and progression in a variety of human cancers.This study aimed to explore the significance of AEG-l in glioma and investigate whether it correlated with radioresistance of glioma cells.Immunohistochemical staining showed that the intensity of AEG-l,CD133 and PPP6 c protein expression in glioma tissues increased significantly,mainly in the cytoplasm.The expression rate of AEG-l,CD133 and PPP6c were 85.9%（67/78）,60.3%（47/78） and 65.8%（51/78）,respectively.AEG-l expression was correlated with age（r=0.227,P=0.045）,clinical stage（r=0.491,P〈0.001） and clinical grade（r=0.450,P〈0.001）.No correlation was found between AEG-l expression and other clinicopathologic parameters（P〉0.05）.The expression of AEG-1 was positively correlated with the expression of CD133（r=0.240,P = 0.035） and PPP6c（r= 0.250,P = 0.027）.In addition,retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-l and PPP6 c in glioblastoma.Our findings indicate that AEG-l is positively correlated with CD133 and AEG-l expression.It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
基金
supported by the National Natural Science Foundation of China(No.81272775)
