帕金森病患者冲动控制障碍及情绪障碍与多巴胺的关系

Relationship between impulsive control disorders,mood dysfunction and dopamine in patients with Parkinson disease

目的探讨帕金森病(PD)患者冲动控制障碍及情绪障碍与多巴胺的关系。方法收集216例PD患者的临床资料,并采用多巴胺失调综合征量表进行评价。计算左旋多巴剂量、左旋多巴等效剂量和总的左旋多巴等效剂量,计数使用多巴胺受体激动剂的例数。分析冲动控制障碍及情绪障碍与多巴胺的关系。结果根据多巴胺失调综合征量表,8例(3.7%)PD患者具有冲动控制障碍,53例(24.5%)PD患者具有情绪障碍。冲动控制障碍组与非冲动控制障碍组年龄、性别、病程、左旋多巴剂量、左旋多巴等效剂量、总的左旋多巴等效剂量、H-Y分期及使用多巴胺受体激动剂的比例、震颤起病的比例差异均无统计学意义。情绪障碍组与非情绪障碍组间这些指标的差异亦无统计学意义。结论 PD患者冲动控制障碍及情绪障碍与左旋多巴剂量、左旋多巴等效剂量、总的左旋多巴等效剂量及使用多巴胺受体激动剂的比例无关。

Objective To investigate the relationship between impulsive control disorders （ICD）,mood dysfunction （MD） and dopamine in patients with Parkinson disease （PD）.Methods The clinical data of 216 PD patients were collected.And they were investigated by a questionnaire of dopamine dysregulation syndrome （DDS）.The dose of levodopa,equivalent dose of levodopa and total equivalent dose of levodopa were calculated,and the number of patients using dopamine agonists was counted.The relationships between ICD,MD and dopamine were analyzed.Results According to the DDS questionnaire,8 patients （3.7％） were diagnosed with ICD behaviors,53 patients （24.5％） had mood dysfunction.The differences of age,sex,disease duration,dose of levodopa,equivalent dose of levodopa,total equivalent dose of levodopa,H-Y stage,the rates of patients using dopamine agonists and onset of tremor between ICD group and non-ICD group were no statistical significance,neither did these items between MD group and non-MD group.Conclusion The dose of levodopa,equivalent dose of levodopa,total equivalent dose of levodopa and the rate of dopamine agonists are not related with ICD as well as MD in patients with PD.