血管周围间隙与多发性硬化的相关性研究

Study on the correlation between perivascular space and multiple sclerosis

目的研究血管周围间隙与多发性硬化的相关性。方法对38例多发性硬化患者(多发性硬化组)及50名健康体检者(对照组)进行头颅MRI检查,计数其血管周围间隙并测量其直径。对结果进行组间比较。结果多发性硬化组患者血管周围间隙检出率(42.1%,16/38)明显高于对照组(16.0%,8/50)(P<0.01)。多发性硬化组患者血管周围间隙的数目[(5.4±2.4)个/例]明显多于对照组[(2.7±2.0)个/例](P<0.01)。多发性硬化组患者血管周围间隙的直径[(3.0±1.0)mm]明显大于对照组[(2.2±0.7)mm](P<0.05)。线性回归分析显示,对照组中血管周围间隙的数目、直径均与年龄呈正相关(r1=0.857,r2=0.956,均P<0.01)。结论血管周围间隙与多发性硬化有一定的相关性。

Objective To study the correlation between perivascular space and multiple sclerosis.Methods Thirty-eight multiple sclerosis patients （MS group） and 50 normal controls （control group） were detected by brain MRI,and their perivascular spaces were numbered and measured.The results were compared between the two groups.Results The discovery rate of perivascular spaces in MS group （42.1％,16/38） was significantly higher than that in control group （16.0％,8/50） （P ＜ 0.01）.The number of perivascular spaces in MS group [（5.4 ± 2.4）/case] was significantly more than that in control group [（2.7 ± 2.0）/case] （P ＜ 0.01）.The diameter of perivascular spaces in MS group [（3.0 ± 1.0） mm] was significantly larger than that in control group [（2.2 ± 0.7） mm] （P ＜0.05）.Linear regression analysis showed the number,diameter of perivascular spaces in control group were both positive correlated with the age （r1 =0.857,r2 =0.956,all P ＜ 0.01）.Conclusion Perivascular spaces have certain relevance with multiple sclerosis.