血清胱抑素C水平与急性腔隙性脑梗死的相关性研究

Study on the correlation between the serum level of Cystatin C and acute lacunar infarction

目的探讨血清胱抑素C(Cys-C)水平与急性腔隙性脑梗死(ALI)的相关性。方法采集62例ALI患者(ALI组)与57例对照者(对照组)的临床资料,检测两组患者的血清Cys-C水平,并进行组间比较。采用Logistic回归法分析影响ALI的危险因素。采用Spearman等级相关对血清Cys-C水平与ALI严重程度的关系进行分析。结果 ALI组患者高血压病和吸烟的比例及血清Cys-C水平均明显高于对照组(均P<0.01)。Logistic回归分析显示,高血压病、吸烟、血清Cys-C水平升高均为ALI发生的独立危险因素(均P<0.05)。Spearman等级相关分析显示,血清Cys-C水平与ALI的严重程度呈正相关(r=0.230,P=0.012)。结论血清Cys-C水平升高是ALI发生的独立危险因素,且与其严重程度呈正相关。

Objective To investigate the correlation between the serum level of Cystatin C （Cys-C） and acute lacunar infarction （ALI）.Methods Collected the clinical data of 62 ALI patients （ALI group） and 57 cases of controls （control group）.The serum levels of Cys-C were detected and compared between the two groups.The risk factors of ALI were analyzed by Logistic regression analysis,and the relationship between the severity of ALI and the serum level of Cys-C was analyzed by Spearman rank correlation.Results The rates of hypertension,smoking and the serum level of Cys-C in ALI group were significantly higher than that in control group （all P ＜ 0.01）.Logistic regression analysis showed that hypertension,smoking and the increase of the serum level of Cys-C were the independent risk factors of ALI （all P ＜ 0.05）.Spearman rank correlation analysis indicated that the severity of the ALI was positively correlated with the serum level of Cys-C （r =0.230,P =0.012）.Conclusion The increase of the serum level of Cys-C is an independent risk factor of ALI,and which is positively correlated with its severity.