润肠丸加减治疗气血两虚型帕金森病患者便秘30例临床观察

Clinical efficacy of modified Runchang pills in treatment of constipation among patients with qi-blood deficiency type Parkinson's disease: a report of 30 cases

目的:观察润肠丸加减治疗气血两虚型帕金森病患者便秘的临床疗效。方法:将60例气血两虚型帕金森病便秘患者随机分为治疗组和对照组各30例,治疗组予润肠丸加减治疗,对照组予莫沙必利治疗,均治疗2周,观察两组治疗前后的主要症状、体征,治疗结束后评价临床疗效。结果:(1)总有效率治疗组为93.3%,对照组为73.3%,组间疗效比较,差异有统计学意义(P<0.05)。(2)两组排便频次、排便时间、粪便性质及排便困难程度积分治疗前后组内比较,差异均有统计学意义(P<0.05,P<0.01);组间治疗后比较,治疗组优于对照组,差异均有统计学意义(P<0.05)。结论:润肠丸加减治疗气血两虚型帕金森病便秘有较好疗效。

Objective: To observe the clinical efficacy of modified Runchang pills in the treatment of constipation among patients with qi- blood deficiency type Parkinson's disease. Methods: Sixty constipation patients with qi-blood deficiency type Parkinson's disease were randomly divided into treatment group( n = 30) and control group( n =30). The treatment group was given modified Runchang pills,while the control group received mosapride. The course of treatment was two weeks for both groups. After treatment,the improvements in main symptoms and signs were evaluated,and the treatment outcomes were assessed. Results: The treatment group had a significantly higher overall response rate than the control group( 93. 3% vs 73. 3%,P < 0. 05). After treatment,both groups showed significant changes in defecation frequency,defecation time,feces nature,and defecation difficulty score( P < 0. 05 or P < 0. 01),and the treatment group was significantly superior to the control group( P < 0. 05). Conclusion: Modified Runchang pills have good efficacy in treating constipation among patients with qi- blood deficiency type Parkinson's disease.