摘要
以天然产物α-蒎烯为原料,经多步反应,合成得到9个新型α-蒎烯基苯基噻二唑类化合物7a^7i。初步探索了合成条件,并利用FT-IR、1H NMR、13C NMR和ESI-MS等多种手段对目标产物作了分析和表征。初步的生物活性测试表明,在50μg/mL浓度下,目标化合物具有一定的杀菌活性,其中化合物7d对苹果轮纹病菌的抑制率达92.6%(A级活性水平),化合物7a对花生褐斑菌的抑制率达91.8%(A级活性水平)。
Nine novel a-pinene-based phenyl-thiadiazole compounds 7a-7i were synthesized via a multiple-step process using a-pinene as starting material. The synthetic conditions were investigated preliminarily. The targeted compounds were analyzed and characterized by FT-IR,IH NMR,13C NMR and ESI-MS. The preliminary bioassay showed that the targeted compounds exhibited a certain fungicidal activity,in which compound 7d had inhibition rate of 92.6% （A-class activity level） against Physalospora piricola, and compound 7 a had inhibition rate of 91.8% （ A-class activity level） a- gainst Cercopora rachidicola at the concentration of 50 μg/mL.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第10期1574-1579,共6页
Natural Product Research and Development
基金
国家自然科学基金项目(31260164)
广西林产化学与工程重点实验室开放基金项目(GXFC11-02
GXFC12-01)
关键词
Α-蒎烯
噻二唑
合成
杀菌活性
α-pinene
thiadiazole
synthesis
fungicidal activity
