姜黄素抗肿瘤作用机制的研究进展

The Research Progress of Curcumin Antitumor Mechanism

多种恶性肿瘤细胞中表达细胞凋亡抑制蛋白(IAPs),如:Survivin、NAIP、XIAP、Livin等,同样表达抗细胞凋亡Bcl-2家族蛋白。IAPS介导的凋亡抑制可能是肿瘤细胞耐药而存活的原因之一;Bcl-2家族蛋白在抗肿瘤凋亡及促其凋亡中发挥作用。姜黄素具有抗炎、抗氧化、抑制血管新生等,可以通过调控蛋白表达及相关信号通路促进细胞凋亡、抗肿瘤作用。

A variety of tumor cells have expression of the inhibitor of apoptosis proteins（IAPs） such as survivin,NAIP,XIAP and Livin protein,as well as expression of resistance-to-apoptosis Bcl-2 family protein.The apoptosis inhibition mediated by IAPS may be one of the reasons for drug-resistant tumor cell and its survival.The Bcl-2 family proteins also play a role in anti-tumor apoptosis and promote their apoptosis proteins.Curcumin has functions like anti-inflammatory,antioxidant,inhibition of angiogenesis and so on.It can promote cell apoptosis and strengthen the antitumor effects through its regulation of protein expressions and related signaling pathways.