胃瘤安对脾虚小鼠胃肠功能的影响

The Influence of Weiliuan on Stomach- Intestine Functions of Rats of Spleen Deficiency

目的:观察胃瘤安对脾虚小鼠胃动力及肠推进作用的影响。方法:采用大黄建立脾虚小鼠模型后,腹腔注射多巴胺,计算炭末推进率和胃残留率,观察胃瘤安不同组方对多巴胺抑制脾虚小鼠胃蠕动的影响;建立脾虚小鼠模型后,腹腔注射新斯的明,观察胃瘤安对肠推进作用的影响。结果:胃瘤安全方高剂量组、胃瘤安(三棱、莪术)高剂量组对多巴胺致脾虚小鼠的炭末推进率明显降低(P<0.05);胃瘤安全方高剂量组、胃瘤安(三棱、莪术)高剂量组、胃瘤安(无三棱、莪术)低剂量组对多巴胺致脾虚小鼠的胃残留率明显增加(P<0.05或P<0.01);胃瘤安全方高剂量组对新斯的明致脾虚小鼠的炭末推进率明显降低(P<0.05),胃瘤安全方高剂量组、胃瘤安全方低剂量组、胃瘤安(三棱、莪术)高剂量组、胃瘤安(三棱、莪术)低剂量组、胃瘤安(无三棱、莪术)高剂量组、胃瘤安(无三棱、莪术)低剂量组均对新斯的明致脾虚小鼠的胃残留率明显增加(P<0.05或P<0.01)。结论:胃瘤安不同组方均有改善胃动力,调节肠推进运动的作用,以胃瘤安全方作用为佳。

Objective：To observe the influence of Weiliuan on stomach dynamics and intestine propulsive role of rats of spleen deficiency. Methods：Dahuang was adopted to establish the model of rats of spleen deficiency;Dopamine was injected into rats＇ abdominal cavity;The charcoal propulsion rate and the gastric residual rate were calculated;The influence of different formulas of Weiliuan on Dopamine in restraining peristole of rats of spleen deficiency;Rats＇ abdominal cavity was injected into proserine;And the influence of Weiliuan on intestine propulsive role. Results：The charcoal propulsion rates of the total Weiliuan high- dosage group and the Weiliuan- Sanleng- Ezhu high- dosage group on rats of spleen deficiency caused by Dopamine obviously decreased（P〈0.05）;The gastric residual rates of the total Weiliuan high-dosage group and the Weiliuan-Sanleng-Ezhu high-dosage group and the Weiliuan- Without- Sanleng- And- Ezhu low- dosage group on rats of spleen deficiency caused by Dopamine obviously increased（P〈0. 05 or P〈0. 01）;The charcoal propulsion rates of the total Weiliuan high- dosage group on rats of spleen deficiency caused by proserine obviously decreased（P〈0. 05）;The gastric residual rates of the total Weiliuan high- dosage group,the total Weiliuan low- dosage group,the Weiliuan- Sanleng- Ezhu high- dosage group,the Weiliuan- Sanleng-Ezhu low- dosage group,the Weiliuan- Without- Sanleng- And- Ezhu high- dosage group and the Weiliuan- Without- Sanleng- And- Ezhu low- dosage group on rats of spleen deficiency caused by proserine obviously increased（ P〈0. 05 or P〈0. 01）. Conclusion：Different formulas of Weiliuan can improve stomach dynamics and regulate intestine propulsion,and among of them the total Weiliuan formula has the best effect.