摘要
乙醛脱氢酶(acetaldehyde dehydrogenase,ALDH)是人体重要的醛脱氢酶之一,催化体内乙醛氧化为乙酸。在组织细胞中,ALDH能解除醛基的毒害作用,其活性的高低与多种人类疾病密切相关。ALDH主要有ALDH1和ALDH2两种同工酶:ALDH1与多种肿瘤的发生发展及预后有紧密联系,在乳腺癌、结直肠癌及肺癌等疾病中均存在高表达现象;ALDH2的基因多态性在亚洲人中多见,除了与消化道肿瘤、酒精性肝病等消化道疾病息息相关,还与心肌梗死、帕金森病(PD)、白血病等密切相关。近年来,关于ALDH的研究日益增多,现就ALDH与人类疾病之间相互关系的研究现状作一综述。
Aldehyde dehydrogenase（ALDH） is one of the important human aldehyde dehydrogenase catalyzing the oxidation of acetaldehyde to acetic acid in vivo. ALDH can eliminate the toxic effects of aldehyde in tissue cells and its activity is closely related to various human diseases.There are two kinds of ALDH isozymes： ALDH1 and ALDH2. ALDH1 is associated with the development and the prognosis of various tumors and highly expressed in breast cancer, colorectal cancer and lung cancer. Polymorphism of ALDH2 is more common in Asians. In addition to gastrointestinal cancer, alcoholic liver disease and other gastrointestinal diseases, ALDH2 is closely related to myocardial infarction, Parkinson＇s disease（PD）, leukemia and other diseases. In recent years, there are more and more researches on the relationship between ALDH and human diseases. In this paper, the research progress in their relationship was reviewed and summarized.
出处
《酿酒科技》
北大核心
2014年第10期89-91,共3页
Liquor-Making Science & Technology
基金
国家基础医学人才培养基地--能力提高项目(编号J1103604)
