中药外敷联合西药治疗痛风性关节炎Meta分析

Meta Analysis of Herbs for External Use and Western Medicine in Treating Gouty Arthritis

目的:评价中药外敷联合西药对比单纯西药治疗痛风性关节炎的疗效与安全性。方法:从4个中文数据库检索文献,纳入中药外敷联合西药对比单纯西药治疗痛风性关节炎的随机对照试验。数据分析采用RevMan 5.3软件进行分析。结果:最终纳入13个研究。Meta分析结果显示中药外敷联合西药与单纯西药治疗痛风性关节炎比较,在治愈率[OR=2.47,95%CI(1.94,3.14)]、总有效率[OR=4.15,95%CI(2.88,5.99)]和不良反应[OR=3.60,95%CI(1.30,9.98)]方面具有统计学差异。结论:目前国内研究显示中药外敷联合西药治疗痛风性关节炎具有更好的疗效,但须注意预防相应的不良反应。

Objective： To compare clinical effects and the safety of herbs for external use combined with west- em medicine and western medicine only in treating gouty arthritis. Methods： The papers about randomized controlled trials of herbs for external use combined with western medicine in treating gouty arthritis compared with only western medicine were searched from four Chinese databases and included. Data analysis was performed with RevMan 5.3 software. Results： Consequently, 13 studies were included. The results of Meta analysis showed that the comparison between herbs for external use combined with western medicine and western medicine only in treating gouty arthritis had statistical difference in cure rate [OR=2.47, 95%CI （1.94, 3.14）], total effective rate [OR=4.15, 95%CI（2.88, 5.99）] and adverse reaction [OR=3.60, 95%CI（1.30, 9.98）]. Conclusion： Current domestic studies reveal that herbs for external use combined with western medicine in treating gouty arthritis could obtain better effects, but when we use the therapy, we should pay attention to the corresponding adverse reaction.