血府逐瘀汤对肺栓塞患者D-二聚体和肺泡动脉血氧分压差的影响

Influence of Xuefuzhuyu Soup on D-dimer and Alveolar-Arterial Oxygen Pressure Difference of Patients with Pulmonary Embolism

目的:探讨血府逐瘀汤对肺栓塞患者D-二聚体和肺泡动脉血氧分压差[P(A-a)O2]的影响。方法:肺栓塞患者80例随机分为观察组40例,给予血府逐瘀汤治疗;对照组40例,给予对症支持处理。比较两组患者治疗后D-二聚体和P(A-a)O2水平变化情况,并分析不同D-二聚体水平和不同P(A-a)O2水平发生肺栓塞情况。结果:治疗后观察组D-二聚体、P(A-a)O2显著低于对照组(P<0.05);D-二聚体>500μg·L-1者发生肺栓塞的几率显著高于D-二聚体<500μg·L-1者(P<0.05);P(A-a)O2>50 mmHg者发生肺栓塞的几率显著高于P(A-a)O2<50 mmHg者(P<0.05)。结论:血府逐瘀汤能有效改善患者肺泡血氧合状态,D-二聚体联合P(A-a)O2诊断肺栓塞能提高诊断率,尤其是对于D-二聚体超过500μg·L-1,同时P(A-a)O2高于50 mmHg者,要提高临床重视,早期诊断肺栓塞。

Objective： To investigate the influence of Xuefuzhuyu Soup on D-dimer and alveolar-arterial oxygen pressure difference[P（ Aa） O2]of patients with pulmonary embolism. Methods：80 cases with pulmonary embolism were divided into two groups,40 cases with the observation group were used Xuefuzhuyu Soup treatment,the control group with 40 patients were used symptomatic and supportive treatment,then D-dimer and PA-aO2 levels were compared in the two groups and different D-dimer levels and different levels of PA-aO2 with pulmonary embolism were analyzed. Results： After treatment,D-dimer levels and P（ A-a） O2 levels of the observation group were significantly lower than that of the control group（ P〈0. 05）; Ratio of pulmonary embolism of patients with D-dimer 500 μg·L^-1was higher than that of D-dimer 500 μg·L^-1（ P〈0. 05）; Ratio of pulmonary embolism of patients with P（ A-a） O2 50 mmHg ratio was higher than P（ A-a） O2 50 mmHg（ P〈0. 05）. Conclusion： Xuefuzhuyu Soup can effectively improve blood oxygenation status and re-duce alveolar hypercoagulable,P（ A-a） O2 combined with D-dimer can better improve the diagnosis of pulmonary embolism diagnosis,especially for P（ A-a） O2 than 50 mmHg while D-dimer exceed 500 μg·L^-1,and they should improve the clinical importance of early diagnosis of pulmonary embolism.